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. 2022 Apr 8;10:35. doi: 10.1038/s41413-022-00199-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Remyelination after SCI. This figure shows the changes in remyelination after SCI. In the acute phase of SCI, the number of oligodendrocytes is reduced, and the integrity of myelin is disrupted. In the subacute phase of SCI, OPCs are activated and begin to differentiate into new oligodendrocytes. Additionally, a small number of OPCs can differentiates into Schwann cells. endo-NSCs are activated, and some of them differentiate into oligodendrocytes. In the chronic phase of SCI, newborn oligodendrocytes form myelin around spared or regenerated axons