Table 2.

Association between Saknorm and rs7512462 using additive and recessive codings in the CGMS prior to treatment.

Models	Covariate	Effect size	S.E.	P-value
Additive	rs7512462_C	0.072	0.030	0.017
	CFTR-Gating/Other	0.210	0.094	0.025
	CFTR-MF/MF	–0.099	0.099	0.317
	Saknorm new reference equation	–0.244	0.050	1.41 × 10−6
Recessive	rs7512462_CC	0.130	0.057	0.022
	CFTR-Gating/Other	0.208	0.093	0.026
	CFTR-MF/MF	–0.101	0.099	0.307
	Saknorm new reference equation	–0.244	0.050	1.32 × 10−6

Saknorm is a continuous FEV₁- based CF-specific percentile that is normalized and accounts for age, sex and height and is survival adjusted^5,35. Saknorm^5,35 is calculated with FEV₁ measurements taken prior to modulator treatment, if applicable. The combined samples include individuals with gating mutations (n = 89), individuals homozygous for Phe508del (n = 1266) or those with two minimal function (MF) mutations (n = 63). All analyses use the robust covariance matrix estimates by the R package ‘rms’⁶⁶. In addition to rs7512462, both models include a CFTR mutation group indicator, with reference group as homozygous Phe508del. Saknorm new reference equation is an indicator for the reference equation used to calculate Saknorm (Methods) depending on the year the lung function measurement was taken. Individuals with a gating variant, individuals who are homozygous Phe508del or those who carry two MF alleles are included.