Table 5.

Co-expression between SLC26A9 and CFTR using the Human Lung Cell Atlas data⁴⁰.

Cell Type	Number of cells	Zero-inflated negative binomial model			Spearman’s correlation
		Effect size	S.E.	P-value	Rho	P-value
Club	895	−0.00007	0.00125	0.9564	0.05173	0.12196
AT2a	760	0.00035	0.00013	0.0097	0.13215	0.00026
Basal	240	−11.6529	94.6542	0.9020	−0.02365	0.71544
AT1a	421	−8.41119	152.863	0.9561	−0.01178	0.80962
AT2-sa	201	0.00143	0.00122	0.2433	0.28686	0.00004
Differentiating Basal	43	−0.02385	0.01931	0.2168	0.07235	0.64478
AT2 and AT2-s	961	0.00041	0.00014	0.0036	0.16567	<0.0001
AT1, AT2 and AT2-s	1382	0.00048	0.00015	0.0018	0.32261	<0.0001

The effect size estimate from zero-inflated negative binomial model indicates log-ratio relations between CFTR and SLC26A9 expression. Values greater than zero correspond to positive co-expression. Spearman’s correlation estimates (rho) were calculated using log-transformed read counts per million measures for CFTR and SLC26A9. The Spearman’s correlation and the zero-inflated negative binomial model analysis were performed by R function cor.test() and the zeroinfl() function in the package pscl⁹⁰, respectively. All p-values indicate two-sided statistical test results.

^aAT2 Alveolar Epithelial Type 2; AT1 Alveolar Epithelial Type 1; AT2-s Signaling Alveolar Epithelial Type 2