Table 6.

The 10 phenotypes with smallest rs7512462 association p-value obtained from the GWAS ATLAS⁴⁴.

PMID	Domain	Trait	Effect Size	P-value at rs7512462	N	Colocalization P-value
30804560	Respiratory	PEF (UKBB)	0.038	4.33 × 1046	321,047	2.24 x 10−9
30804560	Respiratory	PEF (Meta of UKBB and Spirometa)	0.037	2.74 × 10−44	345,265	2.82 × 10−8
30807572	Gastrointestinal	Meconium ileus in CF	−0.289	1.86 × 10−9	6770	NA
28436984	Reproduction	Age at menarche	−0.021	3.93 × 10−6	252,514	3.63 × 10−8
30804560	Respiratory	FEV1/FVC ratio (Meta of UKBB and Spirometa)	0.01	4.11 × 10−5	400,102	6.03 × 10−9
30804560	Respiratory	FEV1/FVC ratio (UKBB)	0.01	1.44 × 10−4	321,047	2.24 × 10−8
23754948	Metabolic	Waist circumference (male)	0.03	2.2 × 10−4	36,231	7.08 × 10−9
25231870	Reproduction	Age at menarche	−0.023	3.2 × 10−4	132,989	7.41 × 10−9
19430480	Endocrine	Type 1 Diabetes	NA	7.47 × 10−4	7982	NA
23754948	Metabolic	Waist-hip ratio (male)	0.028	7.7 × 10−4	34,629	1.78 × 10−8

The colocalization p-value assesses evidence for common genetic contributions between the corresponding study phenotype and the meconium ileus CF GWAS¹ at chr1:205,895,000-205,921,000 locus. The effect allele in all studies is C, and the other allele is T, except for type 1 diabetes, where the effect size is not reported for the SNP in the original summary statistics from the listed publication (PMID). PheWAS significance level is p < 1.05 × 10⁻⁵ after adjusting for 4756 GWAS in the database (alpha 0.05). UKBB refers to an analysis using the UK Biobank. ‘Colocalization P-value’ represents the p-values from the colocalization analysis calculated here with the CF GWAS summary statistics in Gong et al.¹ for the corresponding phenotype, using LocusFocus⁴⁶ calculated on the chr1: 205,895,000-205,925,000 region in hg19. NA in this column reflects a lack of information available to carry out the colocalization analysis.