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. 2022 Apr 8;13(4):322. doi: 10.1038/s41419-022-04732-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Potential binding sites of hsa_circRNA_0088036 and miR-140-3p. B MiR-140-3p expression in 72 paired human BCa and adjacent normal bladder tissues. C Correlation analysis of miR-140-3p and hsa_circRNA_0088036 was performed with the Pearson’s correlation coefficient. D MiR-140-3p levels were measured in patients with low hsa_circRNA_0088036 (n = 36) and high hsa_circRNA_0088036 (n = 36) expression. E OS curves of BCa patients were analyzed according to miR-140-3p expression. F Relative levels of hsa_circRNA_0088036 in T24 and UMUC3 lysates after RNA pull down using oligo probe or hsa_circRNA_0088036 probe. G Dual luciferase reporter assays demonstrated that miR-140-3p is a direct target of hsa_circRNA_0088036. H An immunoprecipitation assay was performed with primers specific for hsa_circRNA_0088036. I A schematic of hsa_circRNA_0088036 WT and MUT luciferase reporter vectors. J Relative luciferase activities were calculated in cells co-transfected with miR-140-3p mimics and NC and WT or MUT luciferase reporter vectors.