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. 2022 Apr 8;5:47. doi: 10.1038/s41746-022-00590-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Depicted is a graphical overview of the construction of the Community Care Cohort Project (C3PO). C3PO comprises the electronic health record (EHR) data of 520,868 individuals aged 18–90 at the start of sample follow-up, selected from an ambulatory EHR database on the basis of receiving periodic primary care (i.e., ≥2 visits within 1–3 consecutive years, see text). C3PO is structured as an indexed file system containing protected health information-minimized data of various types (bottom panel). The C3PO database can readily accommodate updating of existing data, integration of new data features, and construction of composite disease phenotypes based on multiple data features.