Table 5.
Univariate and multivariate analysis of OS in MDS patients.
| Univariate | Multivariate* | |||||
|---|---|---|---|---|---|---|
| Hazard ratio | 95.0% CI for HR | Hazard ratio | 95.0% CI for HR | |||
| Lower | Upper | Lower | Upper | |||
| AGE in years (≥ 60 vs. < 60) | 1.885 | 1.096 | 3.241 | 1.718 | 0.917 | 3.220 |
| Marrow morphology (SLD vs. MLD vs. EB) | 1.852 | 1.284 | 2.671 | 2.814 | 1.237 | 6.399 |
| Cytogenetic group (good vs. inter vs. poor) | 1.675 | 1.113 | 2.52 | 1.953 | 1.2 | 3.179 |
| BLAST % (< 5% vs. > 5%) | 1.433 | 0.825 | 2.489 | 0.473 | 0.137 | 1.631 |
| IPSS R (low risk vs. high risk) | 2.001 | 1.150 | 3.483 | 0.526 | 0.229 | 1.211 |
| TET2 Mutation | 1.821 | 0.810 | 4.092 | 1.811 | 0.640 | 5.122 |
| ASXL Mutation | 2.556 | 1.075 | 6.075 | 0.604 | 0.197 | 1.856 |
| TP53 Mutation | 6.290 | 2.740 | 14.442 | 5.947 | 2.174 | 16.266 |
| RUNX1 Mutation | 2.376 | 1.065 | 5.304 | 2.879 | 1.164 | 7.122 |
| NRAS Mutation | 3.403 | 1.209 | 9.582 | 2.616 | 0.536 | 12.759 |
| KRAS Mutation | 3.697 | 1.129 | 12.106 | 1.105 | 0.189 | 6.465 |
| NOTCH1 Mutation | 2.507 | .768 | 8.186 | 3.875 | 1.137 | 13.124 |
*Multiple variables were selected for the Cox proportional hazard model: age (≥ 60 vs. < 60 year), marrow morphology (SLD vs. MLD vs. EB), bone marrow blast, IPSS-R, and TET2, ASXL1, TP53, RUNX1, NRAS, KRAS and NOTCH1 gene mutations.