Table 7.

Discrimination for three risk markers measured at baseline and change in discrimination when adding Modified PRACTICAL risk to total PSA and the 4kKscore for the outcome of prostate cancer metastasis or death.

	Modified PRACTICAL risk	Total PSA	Modified PRACTICAL risk + Total PSA	Change in AUC from total PSA alone	4Kscore	Modified PRACTICAL risk + 4Kscore	Change in AUC from 4Kscore alone
All men	0.630	0.782	0.772	−0.009	0.758	0.761	0.003
PSA ≤ 1.0a	0.603	0.595	0.620	0.025	–	–	–
PSA ≥ 3.0b	0.580	0.649	0.655	0.006	0.724	0.724	0.000

^aThe PSA ≤ 1.0 ng/ml cutpoint concerns the clinical decision about the frequency of screening.

^bThe PSA ≥ 3.0 ng/ml cutpoint concerns the clinical decision about biopsy.