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. 2022 Apr 8;5:335. doi: 10.1038/s42003-022-03238-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Recurrent amplicons detected by Amplicon Architect associated with known OAC oncogenes. The number of tumours with detected amplicon is shown above. Y-axis showing copy number of segments spanning each gene, averaged along the length of segment. b Correlation of gene expression (TPM) and copy number of amplicons. c Example of an amplified region spanning CDK12, ERBB2, STAT3 and STAT5B, resembling ecDNA and d Reconstructed amplicon as an extrachromosomal circle containing ERBB2 and a CDK12-STAT5B fusion. e An amplified region spanning EGFR and joining chromosomes 7 and 13, forming an ecDNA and reconstructed as a circle (f).