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. 2022 Apr 8;12:5950. doi: 10.1038/s41598-022-10003-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Anti-PAS antibodies enhance VSD hysteresis. (a-c) Voltage dependence of hERG 1a voltage sensor activation (blue) and deactivation (red) for vehicle controls (a), scFv2.10 (b), and scFv2.12 (c). Fits from ionic currents are shown in gray. Gating currents elicited during the test pulse were integrated, and the resultant gating charge was normalized, plotted as a function of test potential and fitted with a Boltzmann function. (d) The magnitude of hysteresis was quantified by subtracting the V_median of deactivation from the V_median of activation. Hysteresis was significantly larger in the presence of scFv2.10 (n = 14) or the presence of scFv2.12 (n = 6) compared with vehicle control recordings (n = 12). All data are reported as mean ± SEM. * indicates p < 0.05.