Table 3.
Association between wait time and outcomes.
| Outcomes | All patients (n = 383) | Unadjusted analysis | Adjusted analysis | Sensitivity analysis I | Sensitivity analysis II | ||||
|---|---|---|---|---|---|---|---|---|---|
| HR [CI 95%] | p | HR [CI 95%] | p | HR [CI 95%] | p | HR (CI 95%) | p | ||
| All-cause death | |||||||||
| In hospital | 15 (3.9%) | 0.97 [0.93–1.01] | 0.76 | 0.98 [0.95–1.03] | 0.81 | 0.98 [0.91–1.07] | 0.61 | 0.99 [0.96–1.03] | 0.76 |
| At 30 days | 21 (5.5%) | 1.02 [0.99–1.05] | 0.21 | 1.19 [0.99–1.06] | 0.47 | 1.02 [0.98–1.14] | 0.31 | 1.01 [0.96–1.13] | 0.44 |
| At 1 year | 55 (14.4%) | 1.02 [1.003–1.04] | 0.02 | 1.02 [1.002–1.04] | 0.02 | 1.02 [1.001–1.05] | 0.04 | 1.01 [1.001–1.02] | 0.03 |
| Death from Cardiac causes at 1 year | 34 (8.9%) | 0.98 [0.96–1.03] | 0.89 | 1.01 [0.99–1.05] | 0.61 | 1 [0.97–1.035] | 0.80 | 1 [0.97–1.04] | 0.71 |
| Outcomes at 1 year | Odds Ratio [CI 95%] | p | Odds Ratio [CI 95%] | p | Odds Ratio [CI 95%] | p | Odds Ratio [CI 95%] | p | |
|---|---|---|---|---|---|---|---|---|---|
| Re hospitalization for cardiac event | |||||||||
| All | 52 (13.6%) | 1.01 [0.98–1.03] | 0.33 | 1.01 [0.98–1.04] | 0.27 | 1.01 [0.98–1.04] | 0.41 | 1.01 [0.98–1.04] | 0.49 |
| Heart failure | 37 (9.7%) | 1.01 [0.97–1.03] | 0.56 | 1.01 [0.98–1.04] | 0.11 | 1.01 [0.97–1.04] | 0.58 | 1.01 [0.98–1.04] | 0.54 |
| Arrhythmia | 5 (1.3%) | 1.03 [0.88–1.3] | 0.71 | 1.04 [0.88–1.22] | 0.89 | 1.02 [0.88–1.2] | 0.79 | 1.02 [0.88–1.2] | 0.90 |
| Myocardial infarction | 10 (2.6%) | 1.02 [0.95–1.1] | 0.44 | 1.02 [0.96–1.14] | 0.71 | 1.02 [0.96–1.13] | 0.46 | 1.02 [0.96–1.13] | 0.63 |
| Stroke or transient ischemic attack | 11 (2.9%) | 1.01 [0.96–1.06] | 0.85 | 0.99 [0.97–1.02] | 0.71 | 0.99 [0.97–1.02] | 0.80 | 0.99 [0.97–1.02] | 0.77 |
| Bleeding | |||||||||
| All | 74 (19.3%) | 0.99 [0.96–1,009] | 0.23 | 0.99 [0.96–1.007] | 0.21 | 0.99 [0.97–1.006] | 0.19 | 0.99 [0.97–1.009] | 0.31 |
| Minor bleeding | 35 (9.1%) | 0.97 [0.96–1.003] | 0.11 | 0.99 [0.95–1.002] | 0.07 | 0.98 [0.95–1.002] | 0.08 | 0.98 [0.95–1.002] | 0.23 |
| Major bleeding | 15 (3.9%) | 0.99 [0.93–1.027] | 0.50 | 0.98 [0.92–1.029] | 0.49 | 0.98 [0.93–1.029] | 0.57 | 0.98 [0.91–1.029] | 0.73 |
| Life threatening or disabling bleeding | 24 (6.3%) | 1.01 [0.99–1.044] | 0.51 | 1.02 [0.99–1.045] | 0.50 | 1.02 [0.997–1.067] | 0.31 | 1.02 [0.998–1.07] | 0.42 |
| New pacemaker | 56 (14.6%) | 0.99 [0.97–1.02] | 0.55 | 0.99 [0.97–1.02] | 0.65 | 0.99 [0.97–1.02] | 0.71 | 0.99 [0.97–1.02] | 0.63 |
| Acute kidney injury | 27 (7.1%) | 0.99 [0.93–1.023] | 0.67 | 0.99 [0.92–1.024] | 0.72 | 0.99 [0.92–1.025] | 0.86 | 0.99 [0.91–1.026] | 0.71 |
CI confidence interval, HR hazard ratio.
aWait time considered as continuous variable (per week) except for sensitivity analysis I where it was ≤ versus > 12 weeks.
Multivariate adjusted analysis: Adjustment on age, sex, body mass index, STS score, diabetes, chronic kidney disease and severe left ventricular systolic dysfunction (LVEF ≤ 30%).
Sensitivity analysis I: Adjustment on all variables differently distributed between the 2 groups alive or dead (Table 1) and considering wait time as a categorical variable (≤ or > 12 weeks).
Sensitivity analysis II: Adjustment on calendar year periods.