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. Author manuscript; available in PMC: 2023 Jul 1.
Published in final edited form as: Hepatology. 2021 Dec 13;76(1):78–93. doi: 10.1002/hep.32196

Figure 7: Binding of Bmal1 and Rev-erbα to the Crebh promoter.

Figure 7:

(A-B) Livers from (A) chow-fed or (B) chow- and Western diet-fed Bmal1+/+ and Bmal1−/− mice were collected to study the binding of Bmal1, Clock, or Rev-erbα to E-Boxes or RORE in the Creb3l3 promoter by ChIP.

(C-D) Temporal changes in the occupancy of Bmal1, Clock, and Rev-erbα on the Creb3l3 promoter was studied by ChIP and then quantified by qRT-PCR in the livers of (C) Bmal1−/− and Bmal1+/+ and (D) Bmal1fl/fl and L-Bmal1−/− mice.

(E-F) Livers from chow- and Western diet-fed (E) Bmal1+/+ and Bmal1−/− and (F) Bmal1fl/fl and L-Bmal1−/− mice were collected at 12:00 to study the binding of Bmal1, Clock, or Rev-erbα to the Creb3l3 promoter by ChIP and qPCR. Values are represented as mean ± SD. n=6, *** p<0.001, t-test.