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. 2022 Apr 9;28:40. doi: 10.1186/s10020-022-00465-w

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Functional classification of proteomic changes in CACs treated with the serum of PCR + vs Neg donors. A Altered pathways related with up- (red) and down- (green) regulated proteins in CACs + PCR vs CACs + Neg. B Ingenuity (IPA) functional network with proteins up- (red) or down-regulated (green) in CACs + PCR vs CACs + Neg, correlated with viral infection and severe acute respiratory syndrome (SARS), among others. C IPA graphical representation of proteins altered in CACs incubated with the serum of COVID-19 PCR + patients, compared to negative controls, participating in leukocyte extravasation signaling. D Proteins altered in CACs + IgG vs CACs + Neg related to viral pathogenesis and replication