TABLE 2.
MICs for strains and replacement amino acids encoded by codon 149 (GTC) and codon 701 (CGC)
| H. pylori strain | Mutation (replacement amino acid) | MIC (agar dilution) of:
|
|
|---|---|---|---|
| Rifampin | Rifabutin | ||
| DR62a | 0.25 | 0.002 | |
| DR62n | V149F | 16 | 8 |
| 2802A | 0.25 | 0.008 | |
| 2802A | V149Q (glutamine) | 32–64 | 0.5–1 |
| V149H (histidine) | 32 | 0.125–1 | |
| V149K (lysine) | 16 | 2–8 | |
| V149E (glutamate) | 32–64 | 2–8 | |
| V149D (aspartate)a | 32 | 16 | |
| V149F (phenylalanine)a | 32 | 16–64 | |
| V149W (tryptophan) | 32 | 64 | |
| V148I (isoleucine) + V149F | 32 | 2 | |
| R701H (histidine) | 16 | 0.065–0.25 | |
a
Can occur in vivo by point mutation.