Table 1.
Clinical characteristics
| Case | Sex | Age at the first seizure on life (Y) | Age at [11C]K-2-PET | AED at surgery (dose) | Seizure frequency | Location of MRI lesion | Location of scalp-EEG abnormality | Location of ECDs estimated by MEG (total number of ECDs) | Location of FDG-PET hypometablism | Location of [11C]K-2 high uptake | [11C]K-2 uptake in the hippocampus | Surgery | Pathological findings | Seizure outcome (ILAE classification) | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Interictal | Ictal | ||||||||||||||
| 1 | F | 4 | 27 | CBZ(400) LEV(2000) LTG(175) |
1–2/M | L hippocampus (HS) |
L aT | L T | L anterior T (6) |
L T (Diffuse) |
L PHG | None | L ATL | HS | 1 |
| 2 | M | 9 | 53 | CBZ(800) PHT(250) |
1–2/W | R hippocampus (HS) |
R aT | R T | R Temporal pole and L mesial T (52) |
R mesial T | R Temporal tip | None | R ATL | HS | 1 |
| 3 | F | 4 | 40 | LTG(300) CBZ(400) |
1–2/W | L hippocampus (HS) |
L aT | L T | L MTG and cortex facing bottom of occipitotemporal sulcus (2) |
L T (Diffuse) |
L PHG, FG, temporal tip | None | L ATL | HS | 1 |
| 4 | F | 7 | 58 | VPA(800) ZNS(300) CBZ(200) LTG(75) DZP(15) |
1–3/W | R hippocampus (HS) |
R a-mT | Non-localizable | R mesial and lateral T (32) |
R T (Diffuse) |
R MTG, ITG | None | R ATL | HS | 1 |
| 5 | F | 13 | 21 | LCM(400) | 5/M | R Temporal tip (ambiguous) |
R aT > L aT | R T | R and L T (18) |
R T (Diffuse) |
R Amygdala, hippocampus | High uptake | R ATL without hippocampectomy | Heterotopia | 4 |
AED, anti-epileptic drug; aT, anterior temporal; a-mT, anterior-middle temporal; ATL, anterior temporal lobectomy; HS, hippocampal sclerosis; IFG, inferior frontal gyrus; L, left; MTG, middle temporal gyrus; R, right; T, temporal.