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. 2022 Feb 22;4(2):fcac045. doi: 10.1093/braincomms/fcac045

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© The Author(s) 2022. Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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NfL species are increased in Alzheimer’s disease CSF compared with healthy controls. Sequential IP-MS of the three main CSF NfL species identifies increased NfL levels in Alzheimer’s disease dementia (n = 4) compared with controls (n = 6) for each main species. Red lines represent relative amounts of NfL species for individuals with Alzheimer’s disease dementia as determined by the presence of amyloid plaques by PET and very mild dementia (CDR = 0.5) and black lines represent healthy age-matched controls (CDR = 0).