Table 1.
Demographic Data of the Probands and Family Members With FZD4 Mutations
| Probands | Family Members | P Value | |
|---|---|---|---|
| Number | 84 | 50 | 0.279 |
| Male, n, % | 54 | 27 | |
| Female, n, % | 30 | 23 | |
| Age, y, mean ± SD | 7.6 ± 9.9 | 30.0 ± 13.4 | <0.001* |
| FEVR stage | <0.001 | ||
| 1 | 29 | 45 | |
| 2 | 15 | 28 | |
| 3 | 19 | 12 | |
| 4 | 55 | 3 | |
| 5 | 12 | 4 | |
| Others | 38 | 1 | |
| Asymmetry | <0.001 | ||
| Low | 34 | 44 | |
| Medium | 9 | 6 | |
| High | 18 | 0 | |
| Retinal folds, n (%) | 55 (32.7) | 3 (2.9) | <0.0001 |
| Retinal detachment, n (%) | 18 (10.7) | 5 (4.9) | 0.118 |
| TEMPVIA | 0.079 | ||
| Obtuse type | 18 (10.7%) | 4 (3.9%) | |
| Acute type | 15 (8.9%) | 6 (5.9%) | |
| Foveal hypoplasia | 28 (16.7%) | 0 (0%) | <0.0001 |
*
The P values were calculated by Student's t-test. The rest of the P values were calculated by the chi-square test, for those columns with case number <5, Fisher exact test was used.
FEVR, familial exudative vitreoretinopathy; TEMPVIA, temporal midperipheral vitreoretinal interface abnormality.
A low asymmetry referred to a difference of one grade or none between contralateral eyes. A medium asymmetry referred to a difference of two grades between contralateral eyes. A high asymmetry referred to a difference of three, four, or five grades between contralateral eyes.