TABLE 1.
Demographics and Clinical Characteristics of the Cohorts
| Variable | Cohort 1: Patients With Cirrhosis Evaluated for Neurocognitive and Muscular Capacities (n = 119) | Cohort 2: Longitudinal Cohort of Patients With Cirrhosis Referred for Liver Transplantation Evaluation (n = 685) | Cohort 3: Longitudinal Cohort of Patients With Cirrhosis Without HE at Enrollment (n = 296) |
|---|---|---|---|
|
| |||
| Age, years, median (IQR) | 62 (58–68) | 56 (49–61) | 60 (52–66) |
| Sex, female, n (%) | 59 (49.6) | 270 (39) | 128 (43) |
| Non-White patients, n (%) | 6(5) | 96(14.0) | — |
| Body mass index, kg/m2, median (IQR) | 30.7 (26.3–35.7) | 28.6 (24.4–33.6) | 29.3 (25.7–34.0) |
| Etiology of cirrhosis, n (%) | |||
| NAFLD | 41 (34) | 157 (23) | 97 (33) |
| Alcohol | 28 (24) | 166 (24) | 65(22) |
| HCV | 18 15) | 156 (23) | 89 (30) |
| Other | 32 (27) | 206 (30) | 45(15) |
| CCI score, median (IQR) | — | 2(1–3) | 4(1–4) |
| Child-Turcotte-Pugh class | |||
| A/B/C, n | 95/21/2* | — | 207/89/0 |
| Ascites, n (%) | — | 374 (55) | 120 (41) |
| HE, n (%) | — | 268 (39) | 0 |
| MELD-Na score, median (IQR) | 9 (8–13) | 13(10–18) | 9(7–13) |
| Albumin, g/dL, median (IQR) | — | 3.2 (2.7–3.7) | 4.0 (3.6–4.3) |
| CFI score, median (IQR) | 0.348(0.315–0.377) | 0.160 (0.109–0.276) | 0.338 (0.287–0.371) |
| Robust, % | 2.5 | 47.9 | 2.0 |
| Prefrail, % | 7.6 | 23.4 | 14.5 |
| Mildly frail, % | 43.7 | 18.5 | 43.9 |
| Moderate to severely frail, % | 46.2 | 10.2 | 39.5 |
| HFRS, median (IQR) | 45.9(26.2–81.3) | 20.2 (6.3–45.9) | 39.3 (21.5–66.8) |
| Low risk, % | 3.4 | 21.2 | 2.4 |
| Intermediate risk, % | 6.7 | 18.1 | 13.9 |
| High risk, % | 89.9 | 60.7 | 83.8 |
NOTE: Race data not collected for cohort 3.
*
Of the patients, 1 had unknown Child-Turcotte-Pugh class.