TABLE 3.
Test Performance of CFI Measures and Physical Frailty Measures in Cohorts 2 and 3
| Variable | Frailty Outcomes |
|||
|---|---|---|---|---|
| Cohort 2: Longitudinal Cohort of Patients With Cirrhosis Referred for Liver Transplantation Evaluation |
Cohort 3: Longitudinal Cohort of Patients With Cirrhosis Without HE at Enrollment |
|||
| Frail FFI Performance | Dependent for Performance of ADL | Frail Chair-Stand Performance | Falls Within 6 Months | |
|
| ||||
| CFI | ||||
| Sensitivity | 0.13 | 0.65 | 0.54 | 0.62 |
| Specificity | 0.92 | 0.63 | 0.72 | 0.67 |
| NPV | 0.60 | 0.95 | 0.67 | 0.87 |
| PPV | 0.51 | 0.15 | 0.60 | 0.33 |
| AUC | 0.57 | 0.70 | 0.62 | 0.68 |
| HFRS | ||||
| Sensitivity | 0.73 | 0.96 | 0.88 | 0.95 |
| Specificity | 0.48 | 0.17 | 0.46 | 0.19 |
| NPV | 0.72 | 0.98 | 0.67 | 0.94 |
| PPV | 0.49 | 0.10 | 0.46 | 0.24 |
| AUC | 0.66 | 0.63 | 0.63 | 0.67 |
NOTE: Physical frailty was defined as an FFI ≥3, any ADL dependency, chair stands below the median (<10), and any falls within the preceding 6 months. Claims- based frailty was defined as a CFI score ≥0.35 or HFRS >15. AUC was performed using continuous values of the CFI and HFRS.