Table 4.

Uni- and multivariate Hazard Cox regression analysis of RFS in primary cancer biopsies^a

	Univariate			Multivariate
	HR	95% CI	p-values	HR	95% CI	p-values
Age	1.00	.97 1.03	0.888	1.00	.96 1.04	0.970
high vs low pCXCR4/CXCR4 TIC ratio	0.61	.31 1.21	0.161	0.33	.13 .81	0.015
Residual disease <2cm	1.13	.56 2.28	0.724	1.30	.56 3.03	0.542
Residual disease >2cm	3.67	1.62 8.31	0.002	7.79	2.19 27.71	0.002
N of chemotherapy cycles	1.28	1.05 1.55	0.013	2.51	.79 8.03	0.120
FIGO IIIA	0.34	.02 5.72	0.455
FIGO IIIB	0.93	.11 8.04	0.944
FIGO IIIC	1.21	.16 9.03	0.851	0.63	.17 2.29	0.480
FIGO IV	1.48	.18 11.94	0.712	1.07	.24 4.78	0.928

^a Cut-off = 0.1875, n = 36. Multivariate analyses showing Hazard Ratios and p-value for all primary cancer biopsies (n = 35 less than 36 due to missing value) conferred by categorized pCXCR4/CXCR4 TIC ratio in primary cancer biopsies, age, residual disease after cytoreductive surgery, number of chemotherapy cycles and FIGO classification.