Table 1.

The substrates of TBK1 and their corresponding signaling pathways

Pathways	Substrates
IRF3/7-IFN pathway	IRF3 at Ser339/386/396 [146–151] IRF7 Ser471/472 [152, 153] DDX3X at Thr542, Ser543 [42] STAT3 at Ser754, 727 [72, 154] STAT6 at Ser407, Tyr641 [155]
NF-κB signaling	PEL1 Ser76/293, Thr288 [156] IKKβ at Ser177/181 [41] NIK at Ser862 [78] XIAP at Ser430 [157] CYLD at Ser418 [158] RIPK1 at Thr189 [74] p65 NF-κB (RelA) at Ser536 [70, 159, 160] cRel at Ser479/602 [70] IkBα at Ser36 [41, 161] Metadherin at Ser568 [142] ACT1/TRAF3IP2 at Ser162/220/ 233/311 [162]
Mitotic regulators	PLK1 at Ser568, Thr210 [142] CEP170 at multiple sites [80] NuMA at multiple sites [80] Cdc20 at Ser134 [163] Cdh1 at Thr20, Ser39/42/58 /131/151 [163]
AKT-mTor signaling	AKT1 at Thr195/308, Ser378/ 473/476 [2] Raptor at Ser877 [15] mTor at Ser2159/2481 [68, 164] S6K at T421/S424 [165] Sec5 [69] GSK3α at Ser21 [44] SRC at Tyr179 [101]
Autophagy pathway	AMPKα1 at Ser459/476 [39], Thr172 LC3C at Ser93/96 [71] GABARAP-L2 at Ser87/88 [71] p62/SQSTM1 on Ser403/366 [4] mLRRK2 at Ser910/935/995 [166] OPTN at Ser177/473/513 [54, 167] STX17 at Ser202 [73] RAB7A at Ser72 [54]
Adaptor proteins	STING Ser324/326/358/366 [134, 168, 169] TRIF at Ser210/212, Thr214 [169] MAVS at Ser442 [169] MVB12b at Ser222 [170] TANK Ser49/126/178/208/228/257 [99] TRAF2 at Ser11 [171]
Insulin/glucose signaling	IR at Ser994 [25] PDE3B at Ser 318 [172] Exo84 Ser8 [173]
Others	Tau at Ser214/324/356 [27] HTT at Ser13/16 [28] ERα at Ser-305 [174] YAP1 at Thr110/114, Ser128/131 HDAC3 at Ser424 [59]