. 2022 Apr 9;41:135. doi: 10.1186/s13046-022-02352-y

Table 4.

Summary of the in vitro antineoplastic activities of TBK1 inhibitors

Molecule	Findings	Reference
AMX	Inhibits growth of ALL cells (RS4;11 and SEM), displays synergism with TMZ in glioblastoma cells (U87MG) and patient samples, and attenuates the metastatic phenotype in prostate cancer cells (PC3 and DU145).	[247, 272, 273]
Compound II	Can induce apoptosis in lung cancer cells (HCC44, H1993, H2073, and H441), including H358 (K-RAS^G12C) and SK-LU-1 (K-RAS^G12D).	[229]
AZ909	Significantly attenuates the growth of N-RAS-activated melanoma cells (WM1366, SBcl2, and WM1346), displays synergism with MEK inhibitors.	[223]
MMB/CYT387/GS-0387	Decreases viability of AML cells (OCI-AML5, MOLM13, MOLM14, and KASUMI-1).	[15]
UNC6587 PROTAC	Selectively slows the growth of VHL^null ccRCC cells (UMRC6) while leaving VHL^+/+-restored UMRC6 cells unaffected.	[80]