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CRS Protease mechanisms. SARS-CoV-2 spike protein can be cleaved by furin at positions 685–686 and 3CLpro at glutamine positions through CRS mechanisms. The catalytic center of furin is the triad Asp – His – Ser and for 3CL protease is the dyad Cys145 – His41. [James J. Neitzel, Enzyme Catalysis: The Serine Proteases, Nature Education 3(9):21 (2010)].
