Table 1.
A) Significance of vasoconstriction in response to cumulative doses of ANG II between control, BV6(K+)2, BV6(Na+)2, and BV6(TFA)2 incubations obtained from Fig. 2A.
| log[ANGII], M | Control vs. BV6(K+)2 | Control vs. BV6(Na+) | Control vs. BV6(TFA) |
|---|---|---|---|
| −12.0 | No significance | No significance | No significance |
| −11.5 | No significance | No significance | No significance |
| −11.0 | No significance | * p = 0.0493 | * p = 0.0186 |
| −10.5 | *** p = 0.0002 | *** p = 0.0009 | *** p = 0.0009 |
| −10.0 | **** p < 0.0001 | **** p < 0.0001 | **** p < 0.0001 |
| −9.5 | **** p < 0.0001 | **** p < 0.0001 | **** p < 0.0001 |
| −9.0 | **** p < 0.0001 | **** p < 0.0001 | **** p < 0.0001 |
| −8.5 | **** p < 0.0001 | **** p < 0.0001 | **** p < 0.0001 |
| −8.0 | **** p < 0.0001 | **** p < 0.0001 | **** p < 0.0001 |
| −7.5 | **** p < 0.0001 | **** p < 0.0001 | **** p < 0.0001 |
| −7.0 | **** p < 0.0001 | **** p < 0.0001 | **** p < 0.0001 |
| −6.5 | No significance | *** p = 0.0003 | * p = 0.0126 |
| −6.0 | No significance | * p = 0.0135 | No significance |
| −5.5 | No significance | No significance | No significance |
| −5.0 | No significance | No significance | No significance |
|
B) Hill coefficients for angiotensin contraction of rat smooth muscle tissues in the absence and presence* of sarilesin (20nM). | ||
|---|---|---|
| Tissue | Absence of [Sar1Ile8]ANG II | Presence of [Sar1Ile8]ANG II |
| Uterus | 1.4 | 0.8* |
| Portal vein | 1.7 | 0.8* |
| Aorta | 1.9 | 0.9* |