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. 2022 Apr 8;13:148. doi: 10.1186/s13287-022-02828-w

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 9 — GO analysis of top mouse DEGs in rd12 mice retina transplanted with cells and validation by qRT-PCR. Enrichr and PANTHER analyses of DEGs were performed with p < 0.05 using DESeq2 after 8 week cell transplantation. A–C GO term enrichment analysis of upregulated DEGs associated with biological processes, molecular function, and cellular component, respectively, and the x-axis represents the combined score generated by Enrichr (**p ≤ 0.01). D, E Protein classes and pathways upregulated in rd12 + pMSCs and rd12 + RPCs, as determined by PANTHER analysis. The x-axis represents the number of genes associated with each category. F, G Expression of anti-inflammatory and neurogenesis genes in rd12, rd12 + pMSCs and rd12 + RPCs and expression ± SEM normalized to rd12 and r12 + pMSCs, respectively, as determined by qRT–PCR. Symbols, #, & and $ indicate significant difference at p ≤ 0.01 between all experimental conditions: rd12, rd12 + pMSCs and rd12 + RPCs, respectively