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. 2022 Apr 8;15:41. doi: 10.1186/s13045-022-01258-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Compound 1 inhibited malignant gene expression in MLL1-r leukemia Molm-13 cells. a–c Treatment with 1 for 4 days dose-dependently inhibited expression of a HoxA9, b Meis1, and c Myc (*p < 0.05); d Gene profiling followed by gene set enrichment analysis (GSEA) shows that treatment of Molm-13 cells with compound 1 (500 nM for 4 days) recapitulated activities of (1, 2) ENL knockdown (GSE80774) and (3, 4) knockdown of MLL1-AF9 and MLL1-ENL (GSE36592 and Ref. 48). It also significantly (5, 6) reversed expression of HoxA9-regulated target genes (GSE13714), and (7) downregulated Myc target genes (GSE32220)