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. 2022 Apr 8;15:41. doi: 10.1186/s13045-022-01258-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Antitumor activities of ENL-targeting compounds. a Antiproliferative activities of compounds upon 7-day incubation, showing compound 1 inhibited proliferation of MLL1-r leukemia (Molm-13 and MV4;11) and Myc-driven Kasumi-1 (AML) and RPMI8226 and U266 (myeloma) cells, while it had no activity against solid Hela (cervical) and Panc1 (pancreatic) cancer cells; b Time-dependent activity of compound 1 against proliferation of Molm-13 cells; c, d Treatment of Molm-13 cells with compound 1 led to c dose-dependent apoptosis and d differentiation (at 3 μM) with more cells expressing high levels of CD14 (upper) and CD11b (lower); e Treatment with compound 1 (30 mg/kg/day for 13 days) caused no significant changes in blood cell counts; f Treatment with 1 (30 mg/kg/day for Day-3–15) significantly inhibited tumor growth (left) with prolonged survivals (right) in mice with subcutaneously xenografted Molm-13 leukemia