Table 4.

Univariate and multivariate analysis of IRGs signature and clinical characteristics with OS

Gene	Univariate analysis		Multivariate analysis
	P value	Hazard ratio	P value	Hazard ratio
BMI	0.037	0.693(0.491–0.979)	0.095	0.718(0.412–1.062)
Age	0.941	0.985(0.670–1.450)
Gender	0.524	1.228(0.652–2.312)	0.088	1.790(0.922–3.518)
Grade	0.933	1.013(0.754–1.360)
Stage	0.014	1.452(1.080–1.952)
Stage T	0.008	1.493(1.110–2.008)	0.064	1.36(0.98–1.89)
IRGs risk score	0.002	2.602(1.437–4.709)	0.022	2.15(1.12–4.13)
Tumor status	0.081	1.652(0.939–2.906)	0.017	2.48(1.18–5.24)
Family cancer history	0.671	1.130(0.642–1.998)
AFP	< 0.001	2.619(1.489–4.607)	0.012	2.24(1.20–4.21)
Hepatitis B/C	0.088	0.614(0.351–1.075)	0.035	0.73(0.37–1.42)