Table 1.
Characteristics of patients with CTEPH and control participants
| Factor | Group | Control | CTEPH | P-value |
|---|---|---|---|---|
| (n = 22) | (n = 11) | |||
| Age | Years | 65.5 ± 11.6 | 65.5 ± 12.2 | 0.94 |
| Sex | Female/male | 14-Aug | 07-Apr | 1 |
| BMI | 23.0 ± 4.3 | 23.7 ± 6.1 | 0.89 | |
| History of acute PE | No data | 9 | ||
| History of DVT | No data | 5 | ||
| Disease duration from onset to diagnosis | (months) | No data | 52.5 ± 56.9 | |
| NYHA classification | 1/2/3/4 | No data | 0/7/4/0 | |
| Location of thrombus* | No data | Main PA: 6 | ||
| Lobar PA: 4 | ||||
| Segmental PA: 1 | ||||
| Hemodynamics | ||||
| Mean PAP | (mmHg) | No data | 44.1 ± 9.1 | |
| PAR | (dyne sec cm−5) | No data | 748 ± 254 | |
| CI | (L/min/m2) | No data | 2.43 ± 0.51 | |
| Medication | ||||
| Proton pump inhibitors | 2 | 6 | < 0.01 | |
| Antibiotics | 0 | 0 | 1 | |
| Laxatives | 0 | 0 | 1 | |
| Antiflatulents | 0 | 1 | 0.3 | |
| sGC stimulators | 0 | 8 | < 0.01 |
*The most proximal site where chronic thromboembolism started within the pulmonary arteries assessed using enhanced computed tomography scan and pulmonary angiography. BMI, body mass index; PE: pulmonary embolism; DVT: deep vein thrombosis; CI, cardiac index; NYHA: New York Heart Association; PA, pulmonary artery; sGC, soluble guanylate cyclase; CTEPH, chronic thromboembolic pulmonary hypertension; PAP, pulmonary arterial pressure; PAR, pulmonary arterial resistance