Table 2.
Histological characteristics of BMD patients and controls
| Study participants | |||
|---|---|---|---|
| BMD (n = 45) |
Controls (n = 15) |
Adjusted P value a | |
|
CSA I (µm2) Fibre size |
4074 (2852–5833) | 3991 (3387–4695) | 1 |
|
CSA I Fibre size variability |
3316 (2246–4799) | 1200 (814–1463) | 0.0001 |
|
CSA II (µm2) Fibre size |
4680 (2649–5978) | 4681 (3333–5604) | 1 |
|
CSA II Fibre size variability |
4511 (3733–6506) | 1623 (1241–2231) | 0.0001 |
| Nuclear Centralizations % | 4.5 (3–5) | 1 (0–1.5) | 0.0001 |
| Regenerating fibres % | 3.4 (0–6.82) | 0 (0–0) | 0.0001 |
| MFA % | 76.84 (62.68–83.10) | 90.85 (88.91–92.01) | 0.0001 |
| Fatty tissue % | 0 (0–0) | 0 (0–0) | 0.0001 |
| Range | 0–16.52 | 0–0.001 | |
| Fibrotic tissue % | 22.45 (15.89–34.70) | 9.15 (7.72–10.76) | 0.0001 |
| Other tissue % | 0 (0–0) | 0 (0–0) | 0.39 |
| Range | 0–3.3 | 0–0.24 | |
| Splitting fibres % | 3.1 (1.03–5.74) | 0 (0–0) | 0.0001 |
| Necrosis fibres % | 0.79 (0–1.54) | 0 (0–0) | 0.0052 |
Statistically significant p values are shown in bold
Data are given as median (interquartile range). a Mann–Whitney U test
BMD: Becker Muscular Dystrophy; CSA: cross sectional area; MFA: muscle fibre area