Table 2.
Baseline characteristics of study participants and non-responders by common SNPs of GCKR genotypes
| Variables | Male | Female | ||||
|---|---|---|---|---|---|---|
| Responders (%) | Non-Responders (%) | P value | Responders (%) | Non-Responders (%) | P value | |
| Group size (%) | 2164 (72.28) | 830 (27.72) | 2590 (68.28) | 1203 (31.72) | ||
| Age(mean ± SD) | 39.35 ± 14.59 | 41.48 ± 15.31 | 0.06141 | 36.25 ± 11.51 | 37.06 ± 14.6 | 0.0649a |
| Schooling years (mean ± SD) | 10.02 ± 4.65 | 9.91 ± 4.4 | 0.5821 | 9.58 ± 4.4 | 9.32 ± 4.36 | 0.145a |
| BMI (mean ± SD) | 24.86 ± 3.87 | 25.12 ± 4.38 | 0.02461 | 26.31 ± 4.68 | 26.63 ± 4.92 | 0.0539a |
| Physical activity (mean ± SD) | 607.79 ± 1049.11 | 524.49 ± 1034.92 | 0.05101 | 429.78 ± 696.21 | 384.48 ± 682.76 | 0.0607a |
| Smoking status (%) | ||||||
| Never smoker | 825 (38.12) | 283 (34.10) | 0.2212 | 1732 (66.87) | 717 (59.60) | 0.002b |
| Former smoker | 219 (10.12) | 88 (10.60) | 8 (0.31) | 13 (1.08) | ||
| Current smoker | 547(25.28) | 196 (23.61) | 59 (2.28) | 35 (2.91) | ||
| Second hand | 573(26.48) | 171 (20.60) | 791 (30.54) | 371 (30.84) | ||
| Marital status (%) | ||||||
| Divorced | 12 (0.55) | 1(0.05) | 0.1042 | 33 (1.27) | 18 (1.50) | < 0.001b |
| Married | 1628 (75.23) | 649(29.99) | 2011 (77.64) | 954 (79.30) | ||
| Single | 520 (24.03) | 176 (8.13) | 462 (17.84) | 155 (12.88) | ||
| Widowed | 4 (0.18) | 3 (0.14) | 84 (3.24) | 76 (6.32) | ||
| rs1260326 (%) | ||||||
| CC | 662 (30.59) | 265 (31.93) | 0.2332 | 755 (29.15) | 370 (30.76) | 0.602b |
| TC | 1015 (46.90) | 402 (48.43) | 1265 (48.84) | 574 (47.71) | ||
| TT | 487 (22.50) | 163 (49.64) | 570 (22.01) | 259 (21.53) | ||
| rs780094 (%) | ||||||
| CC | 676 (31.24) | 251 (30.24) | 0.302 | 773 (28.30) | 358 (29.76) | 0.998b |
| TC | 1015 (46.90) | 414 (49.88) | 1256 (48.49) | 584 (48.55) | ||
| TT | 473 (21.86) | 165 (19.88) | 561 (21.66) | 261 (21.70) | ||
| rs780093 (%) | ||||||
| CC | 672 (31.05) | 179 (21.57) | 0.1762 | 754 (29.11) | 280 (23.28) | 0.087b |
| TC | 1010 (46.67) | 315 (37.95) | 1275 (49.23) | 404 (33.58) | ||
| TT | 482 (22.27) | 125 (15.06) | 561 (21.66) | 214 (17.79) | ||
BMI Body Mass Index; There were no significant differences between responders and non-responders in males and females other than higher BMI and lower physical activity in male non-responders and different smoking and marital status distribution between female responders and non-responders
aStudent's t-test
bchi-square test