Table 1.
Role of hnRNP C regulation and dysregulation in cancers
| Cancer | hnRNP C Imbalance type |
Interacting molecule | Consequence |
|---|---|---|---|
| Nonsmall Cell Lung Cancer (NSCLC) | Up regulated | KHSRP protein | IFN-α-JAK-STAT1 axis activated, promoting invision and metastasis [38]. |
| Glioblastoma multiform (GBM) | Up regulated | MiR-21 |
PDCD4 decreased. Promoting Migration and invision [42]. |
| Ovarian serous cystadeno carcinoma | Up regulated | MiR-774-5p |
Bcl2 levels downregulated. Promoting apoptotic [43]. |
| Brain-trophic metastatic MDA-MB-435-LvBr2 (LvBr2) cells | UP regulated | MiR-146a | Promoting Migration and invision of LvBr2 cells [44]. |
| Esophageal squamous cell carcinoma (ESCC) | Up regulated | LBX2-AS1 (lncRNA) |
enhance the stability of ZEB1 and ZEB2 mRNAs. promoting cell EMT and migration in ESCC [45]. |
| Oral squamous cell carcinoma (OSCC) | Up regulated | LINC00662 |
regulate AK4 mRNA stability. reduced the radiosensitivity of OSCC cells [46]. |
| Breast cancer | Down regulated | dsRNA |
trigger IFN response inhibit proliferation and tumor growth [35]. |
| Colon cancer | Up regulated | URT of gene | drive CR- and UTR-APA in MTHFD1L [40]. |
| Most of cancers | Up regulated. |
As a reader Of m6A |
has a potential as a biomaker. |