Table 1.
Summary of the studies included and their main data.
| Article | Study type | Total sample/Valid patients | Centers number/Location | Nutritional state – Criterion | Age (IQR, medium age) | Weight excess | PICU Necessity | Assessed outcomes | Searched for relation between weight excess and severe COVID-19 ∗ |
|---|---|---|---|---|---|---|---|---|---|
| Zahra Belhadjer et al. [30] | Retrospective cohort | 35/31 | 12 -France; 1 - Switzerland | Obesity = overweight = BMI >25 | 2-16 y; 10 y | 6 (17%) | 82,85% | MIS-C, ECMO, PICU, Mortality | |
| Philip Zachariah et al. [26] | Case series | 50/50 | 1- New York (USA) | Overweight p85-95/Obesity > p95 (CDC) | 6 d-21 y; NA | Total obesity 22%/Overweight 16% | NA | MV, ECMO, Mortality | ∗ |
| Jerry Y Chao et al. [27] | Retrospective cohort | 67/46 | 1- New York (USA) | Obesity = BMI >30 | 0.4–19.3 y; 13.1 y | 14 (30.4%) | 13 (28,3%) | ARDS, PICU, MV, Mortality | ∗ |
| Nadia Nathan et al. [37] | Retrospective cohort | 23/23 | 1 - France | BMI Z score | 0.1–17.6 y; 4.9 y | Obesity/Overweight 3 (13%) | 5/21 (24%) | Mortality, PICU, ARDS, MIS-C, MV | |
| William R. Otto et al. [32] | Retrospective cohort series | 7256/77 | NA - USA | NA | 1.1y-15.4 y; 9.9 y | 55/424 (13%) | 25/77 (32.9%) | Mortality, PICU, ARDS, MIS-C, MV, ECMO | |
| Yanli Wang et al. [24] | Retrospective control–case | 260/43 | 1 - China | BMI | 0.97y–13.83 y; 6.9 y | 18 average BMI | NA | MV, Mortality | ∗ |
| Sthepanie Lovinsky-Desir et al. [28] | Retrospective cohort | 1298/55 | 3 - New York (USA) | BMI >30 | Mean age 14 y between <21 y | 10/55 (18%) | NA | MV, Mortality | ∗ |
| Christine A. Capone et al. [38] | Case series | 33/33 | 1- New York (USA) | Overweight p85-95/Obesity p > 95 | 5.5 y-12.6 y; 8.6 y | Obesity 13 (39%)/Overweight 2 (6%) | 26/33 (79%) | MV, Mortality, MIS-C, PICU | |
| Roberta L. DeBiasi et al. [29] | Retrospective cohort | 177/44 | 1 - Washington (USA) | NA - Banco de dados | 0.1y-25.6 y; 9.6 y | 1/44 (2%) | 9/44 (20.4%) | Mortality, MV, MIS-C, PICU, ARDS | ∗ |
| Safiya Richardson et al. [25] | Case series | 5700/50 | 12 - New York (USA) | Obesity (BMI > or equal to 30)/Morbid (BMI > or equal to 35) | 0-10.7 y; 6.3 y | 1737/4170–41.7% | 7/46 (12.2%) | PICU, MV, Mortality | |
| Einat Blumfield et al. [33] | Retrospective cohort | 19/19 | 1 - New York (USA) | NA | 2 m-18 y; 8 y | 3 (15.8%) | 14/19 (73.7%) | Mortality, ARDS, MV, MIS-C, PICU |
Caption: IQR - Interquartile range; MIS-C - Multisystem inflammatory syndrome in children; ECMO - Extracorporeal membrane oxygenation; BMI - Body mass index; PICU - Pediatric intensive care unit; NA - Not available; USA–United States of America; CDC - Center for Disease Control; MV - Mechanical ventilation; ARDS - Acute Respiratory Distress Syndrome.