Table 3.
Analysis of outcomes by type of cooling*
| Outcome | Overall | Whole-body cooling | Selective head cooling |
|---|---|---|---|
|
Neonatal mortality
|
0.87 (0.75, 1.00), N = 22, n = 2434, I2 = 38% |
0.88 (0.76, 1.02), N = 17, n = 2172, I2 = 50% |
0.47 (0.16, 1.32), N = 5, n = 262, I2 = 0% |
|
Mortality at 18-24 mo
|
0.88 (0.78, 1.01), N = 11, n = 2042, I2 = 51% |
0.91 (0.79, 1.06), N = 8, n = 1608, I2 = 62% |
0.79 (0.59, 1.05), N = 3, n = 434, I2 = 0% |
|
Mortality at 5-10 y of age
|
0.81 (0.62, 1.04), N = 2, n = 515, I2 = 59% |
0.81 (0.62, 1.04), N = 2, n = 515, I2 = 59% |
No trial |
|
Neurological disability at 18-24 mo
|
0.62 (0.52, 0.75), N = 11, n = 1440, I2 = 26% |
0.65 (0.53, 0.80), N = 7, n = 1095, I2 = 15% |
0.54 (0.36, 0.81), N = 4, n = 345, I2 = 48% |
|
Neurological disability at 5-10 y of age
|
0.68 (0.52, 0.90), N = 3, n = 442, I2 = 3% |
0.68 (0.52, 0.90), N = 3, n = 442, I2 = 3% |
No trial |
|
Mortality or disability at 18-24 mo
|
0.78 (0.72, 0.86), N = 10, n = 1914, I2 = 54% |
0.79 (0.72, 0.88), N = 7, n = 1480, I2 = 67% |
0.75 (0.63, 0.91), N = 3, n = 434, I2 = 0% |
|
Cerebral palsy at 18-24 mo
|
0.63 (0.50, 0.78), N = 8, n = 1136, I2 = 39% |
0.66 (0.52, 0.83), N = 7, n = 989, I2 = 41% |
0.44 (0.22, 0.88), N = 1, n = 147 |
|
Cerebral palsy at 5-10 y of age
|
0.63 (0.46, 0.85), N = 3, n = 449, I2 = 0% |
0.63 (0.46, 0.85), N = 3, n = 449, I2 = 0% |
No trial |
|
Neonatal seizures
|
1.02 (0.95, 1.09), N = 10, n = 1094, I2 = 17% |
1.03 (0.95, 1.11), N = 8, n = 843, I2 = 23% |
0.99 (0.87, 1.12), N = 2, n = 251, I2 = 55% |
|
Seizures at 18-24 mo (infantile epilepsy)
|
0.87 (0.55, 1.37), N = 4, n = 710, I2 = 36% |
0.84 (0.48, 1.48), N = 3, n = 571, I2 = 56% |
0.93 (0.43, 2.00), N = 1, n = 139 |
| Seizures at 5-10 y of age (childhood epilepsy) | 0.65 (0.25, 1.68), N = 1, n = 117 | 0.65 (0.25, 1.68), N = 1, n = 117 | No trial |
mo – months, y – years
*All data are presented as risk ratios (RR) with 95% CI. ‘N’ represents the number of trials, and ‘n’ represents the number of participants.