Figure 5.

Surrogate neutralization assay (spike protein [S] and receptor-binding domain [RBD]), with mapping to the final predicted titers at plateau. A, B, Percentage of binding plotted against antibody titers. Red lines represent the median antibody titer at which the change in percentage binding is greatest; dotted red lines, 95% confidence intervals (CIs). Black lines represent the median posterior distribution of the generalized logistic model, and blue shading, 95% CIs. C, D, Posterior distribution of antibody titers at the long-term plateau, as predicted by the gamma-plateau model; shaded gray areas represent thresholds of seronegativity. Abbreviations: MSD, Meso Scale Discovery assay; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.