TABLE 1.
Characteristics of SARS‐CoV‐2 variants
| Classification a | WHO label | Pango lineage | Mutations in RBD of the spike protein a | Mutations in the rest of the spike protein a |
|---|---|---|---|---|
| VOC | Omicron | B.1.1.529 (BA.1) | G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H | A67V, HV69‐70Del, T95I, G142D, VYY143‐145Del, N211Del, L212I, Ins214EPE, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F |
| BA.2 | G339D, S371F, S373P, S375F,T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H | T19I, LPP24‐26Del, A27S, G142D, V213G, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K | ||
| BA.3 | G339D, S371F, S373P, S375F, D405N, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H | A67V, HV69‐70Del, T95I, G142D, VYY143‐145Del, N211Del, L212I, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K | ||
| Alpha | B.1.1.7 | N501Y | HV69‐70Del, Y144Del, A570D, D614G, P681H, T716I, S982A, D1118H | |
| Beta | B.1.351 | K417N, E484K, N501Y | L18F, D80A, D215G, LAL242‐244Del, D614G, A701V | |
| Gamma | P.1 | K417T, E484K, N501Y | L18F, T20N, P26S, D138Y, R190S, D614G, H655Y, T1027I, V1176F | |
| Delta | B.1.617.2 | L452R, T478K | T19R, G142D, EF156‐157Del, R158G, D614G, P681R, D950N | |
| VOI | Lambda | C.37 | L452Q, F490S | G75V, T76I, RSYLTPG246‐252Del, D253N, D614G, T859N |
| Mu | B.1.621 | R346K, E484K, N501Y | T95I, Y144S, Y145N, D614G, P681H, D950N | |
| VUM | C.1.2 | Y449H, E484K, N501Y | P9L, C136F, Y144Del, R190S, D215G, AL243‐244Del, D614G, H655Y, N679K, T716I, T859N | |
| B.1.630 | L452R, T478R, E484Q | P9L, C136F, Y144Del, A222V, AL243‐244Del, D614G, H655Y, D950N | ||
| B.1.640.1 | R346S, N394S, Y449N, F490R, N501Y | P9L, E96Q, CNDPFLGVY136‐144 Del, R190S, I210T, D614G, P681H, T859N, D936H | ||
| B.1.640.2 | R346S, N394S, Y449N, E484K, F490S, N501Y | P9L, E96Q, CNDPFLGVY136‐144 Del, R190S, D215H, D614G, P681H, T859N, D1139H |
Note: The spike protein mutations of the SARS‐CoV‐2 variants used in this study are listed.
Abbreviations: RBD, receptor‐binding domain; VOC, variants of concern; VOI, variants of interest; VUM, variants under monitoring.
a
The classification of variant strains is regularly adjusted based on the SARS‐CoV‐2 continuous evolution and spread, as well as a better understanding of the impact of the variants. As a result, the classification of variants is dynamic, constantly being removed or added.
b
The mutation sites of the variants represent the characteristics of most sequences, and individual mutation sites can only be detected in partial sequences, which are not shown here.