Table 3.
Univariate and Multivariate Cox Regression Analysis for Predicting Overall Survival in Hepatocellular Carcinoma Treated by Transarterial Chemoembolization in the Training Cohort
| Variable | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Gender | 1.480(0.671–3.264) | 0.358 | – | |
| Age | 0.996(0.973–1.020) | 0.751 | – | |
| Etiology | 1.544(0.701–3.403) | 0.258 | – | |
| BCLC‐stage | 2.225(1.315–3.766) | 0.003 | 2.712(0.294–25.040) | 0.382 |
| Child‐Pugh class | 2.293(1.293–4.065) | 0.008 | 1.427(0.741–2.748) | 0.290 |
| Longest diameter | 1.010(1.004–1.017) | 0.002 | 1.004(0.995–1.013) | 0.378 |
| Tumor number | 1.007(0.602–1.686) | 0.978 | – | |
| Pre‐vascularization | 2.983(1.802–4.977) | < 0.0001 | 0.940(0.682–1.295) | 0.705 |
| Pre‐pseudocapsule | 1.656(0.979–2.801) | 0.065 | – | |
| Pre‐cirrhosis (CT) | 1.165(0.570–2.377) | 0.682 | – | |
| Pre‐thrombus | 2.209(1.302–3.746) | 0.005 | 0.489(0.057–4.226) | 0.518 |
| Pre‐AFP | 2.431(1.447–4.085) | 0.001 | 1.442(0.769–2.704) | 0.257 |
| Pre‐ALB | 0.6531(0.391–1.092) | 0.106 | – | |
| Pre‐ALT | 0.878(0.526–1.466) | 0.620 | – | |
| Pre‐AST | 1.222(0.672–2.224) | 0.507 | – | |
| Post‐ALB | 0.806(0.484–1.342) | 0.410 | – | |
| Post‐ALT | 0.888(0.515–1.532) | 0.673 | – | |
| Post‐AST | 1.929(0.700–5.321) | 0.507 | – | |
| Post-response | 2.091(1.501–2.915) | < 0.0001 | 1.880(1.310–2.697) | 0.0007* |
| Radscore | 2.305(1.551–3.426) | < 0.0001 | 2.065(1.285–3.316) | 0.0029* |
Note: *P<0.05, the difference is statistically significant.
Abbreviations: HR, hazard ratio; CI, confidence interval.