Table 2.
Upregulated genes after exposure to Gulf War insult. Red, positive fold changes indicate upregulation.
| Symbol | Entrez Gene Name | RPKM | FC | P-value |
|---|---|---|---|---|
| Lars2 | Leucyl-tRNA synthetase 2, mitochondrial | 744.328 | 1.542 | 4.48E-05 |
| Gdf1 | Growth differentiation factor 1 | 11.348 | 1.454 | 0.0081 |
| Cdr1 | Cerebellar degeneration related antigen 1 | 23.178 | 1.441 | 0.017 |
| Fam126b | Family with sequence similarity 126 member B | 12.032 | 1.390 | 0.0548 |
| Pak3 | p21 (RAC1) activated kinase 3 | 14.277 | 1.387 | 0.00816 |
| Igip | IgA inducing protein | 31.362 | 1.377 | 0.0179 |
| Pgm2l1 | Phosphoglucomutase 2 like 1 | 45.308 | 1.376 | 0.0244 |
| Smc3 | Structural maintenance of chromosomes 3 | 11.216 | 1.367 | 0.0357 |
| Dgkb | Diacylglycerol kinase beta | 20.952 | 1.365 | 0.0343 |
| Atrx | ATRX chromatin remodeler | 10.147 | 1.359 | 0.0912 |
| Ppp4r2 | Protein phosphatase 4 regulatory subunit 2 | 14.623 | 1.359 | 0.0345 |
| Ankrd12 | Ankyrin repeat domain 12 | 10.712 | 1.357 | 0.0856 |
| Hspa4l | Heat shock protein family A (Hsp70) member 4 like | 12.354 | 1.357 | 0.0544 |
| Ppig | Peptidylprolyl isomerase G | 11.563 | 1.354 | 0.0353 |
| Rabep1 | Rabaptin, RAB GTPase binding effector protein 1 | 16.266 | 1.345 | 0.019 |
| Dnajb4 | DnaJ heat shock protein family (Hsp40) member B4 | 11.871 | 1.343 | 0.0384 |
| Pcmtd1 | Protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 | 16.76 | 1.340 | 0.0856 |
| Reps2 | RALBP1 associated Eps domain containing 2 | 21.405 | 1.340 | 0.034 |
| Ube2q2 | Ubiquitin conjugating enzyme E2 Q2 | 13.79 | 1.332 | 0.0259 |
| Rab3c | RAB3C, member RAS oncogene family | 44.551 | 1.330 | 0.0242 |
| Acbd5 | Acyl-CoA binding domain containing 5 | 11.406 | 1.326 | 0.0703 |
| Fmr1 | FMRP translational regulator 1 | 11.502 | 1.324 | 0.0571 |
| Tax1bp1 | Tax1 binding protein 1 | 22.074 | 1.320 | 0.0419 |
| Nus1 | NUS1 dehydrodolichyl diphosphate synthase subunit | 16.346 | 1.319 | 0.0104 |
| Hsp90aa1 | Heat shock protein 90 alpha family class A member 1 | 213.841 | 1.318 | 0.0268 |
| Gmfb | Glia maturation factor beta | 35.439 | 1.317 | 0.0425 |
| Gpbp1 | GC-rich promoter binding protein 1 | 17.787 | 1.313 | 0.0663 |
| Naa50 | N(alpha)-acetyltransferase 50, NatE catalytic subunit | 16.618 | 1.312 | 0.0269 |
| Gabra2 | Gamma-aminobutyric acid type A receptor alpha2 subunit | 36.465 | 1.309 | 0.0647 |
| Fxr1 | FMR1 autosomal homolog 1 | 11.598 | 1.308 | 0.0792 |
| Kpna3 | Karyopherin subunit alpha 3 | 16.133 | 1.308 | 0.0695 |
| Ipo7 | Importin 7 | 17.7 | 1.307 | 0.0853 |
| Mphosph8 | M-phase phosphoprotein 8 | 15.901 | 1.307 | 0.027 |
| Kif5b | Kinesin family member 5B | 33.739 | 1.305 | 0.0762 |
| Psd3 | Pleckstrin and Sec7 domain containing 3 | 26.285 | 1.304 | 0.0549 |
| Pde1a | Phosphodiesterase 1A | 26.28 | 1.298 | 0.0265 |
| Mob4 | MOB family member 4, phocein | 14.856 | 1.297 | 0.0703 |
| Uba3 | Ubiquitin like modifier activating enzyme 3 | 13.952 | 1.289 | 0.086 |
| Slc8a1 | Solute carrier family 8 member A1 | 11.848 | 1.287 | 0.0454 |
| Ankrd13c | Ankyrin repeat domain 13C | 19.116 | 1.286 | 0.0179 |
| Pten | Phosphatase and tensin homolog | 20.14 | 1.286 | 0.0542 |
| Eif3a | Eukaryotic translation initiation factor 3 subunit A | 27.913 | 1.284 | 0.0128 |
| Gabrb1 | Gamma-aminobutyric acid type A receptor beta1 subunit | 13.845 | 1.282 | 0.0663 |
| Ogfrl1 | Opioid growth factor receptor like 1 | 36.947 | 1.277 | 0.0141 |
| Selenot | Selenoprotein T | 44.851 | 1.277 | 0.0616 |
| Eif5 | Eukaryotic translation initiation factor 5 | 34.859 | 1.276 | 0.0662 |
| Htatsf1 | HIV-1 Tat specific factor 1 | 18.843 | 1.275 | 0.0447 |
| Top1 | DNA topoisomerase I | 22.617 | 1.275 | 0.0196 |
| Slc25a46 | Solute carrier family 25 member 46 | 11.765 | 1.272 | 0.084 |
| Nrxn1 | Neurexin 1 | 30.941 | 1.269 | 0.0682 |
| Gad2 | Glutamate decarboxylase 2 | 17.309 | 1.268 | 0.0356 |
| Fgfr1op2 | FGFR1 oncogene partner 2 | 25.756 | 1.267 | 0.0296 |
| Hspa5 | Heat shock protein family A (Hsp70) member 5 | 46.918 | 1.267 | 0.00428 |
| Zc3h15 | Zinc finger CCCH-type containing 15 | 34.721 | 1.266 | 0.0177 |
| Armcx3 | Armadillo repeat containing X-linked 3 | 22 | 1.264 | 0.0541 |
| Hnrnpa3 | Heterogeneous nuclear ribonucleoprotein A3 | 29.364 | 1.263 | 0.0946 |
| Senp6 | SUMO specific peptidase 6 | 10.207 | 1.263 | 0.0819 |
| Fbxo11 | F-box protein 11 | 23.116 | 1.261 | 0.062 |
| Cert1 | Ceramide transporter 1 | 11.829 | 1.257 | 0.0968 |
| Oxr1 | Oxidation resistance 1 | 23.222 | 1.257 | 0.0785 |
| Impact | Impact RWD domain protein | 38.33 | 1.252 | 0.0648 |
| Psip1 | PC4 and SFRS1 interacting protein 1 | 32.895 | 1.252 | 0.0289 |
| Slmap | Sarcolemma associated protein | 13.2 | 1.252 | 0.0502 |
| Fgf12 | Fibroblast growth factor 12 | 10.635 | 1.249 | 0.0679 |
| Sucla2 | Succinate-CoA ligase ADP-forming beta subunit | 33.008 | 1.249 | 0.0601 |
| Dld | Dihydrolipoamide dehydrogenase | 28.74 | 1.248 | 0.0389 |
| Negr1 | Neuronal growth regulator 1 | 18.551 | 1.246 | 0.0251 |
| Acsl4 | Acyl-CoA synthetase long chain family member 4 | 13.462 | 1.242 | 0.0806 |
| Dnaja1 | DnaJ heat shock protein family (Hsp40) member A1 | 37.903 | 1.242 | 0.0162 |
| Pnrc2 | Proline rich nuclear receptor coactivator 2 | 13.435 | 1.242 | 0.0808 |
| Eif5b | Eukaryotic translation initiation factor 5B | 11.453 | 1.240 | 0.0354 |
| Mib1 | Mindbomb E3 ubiquitin protein ligase 1 | 15.309 | 1.239 | 0.0985 |
| Plcb1 | Phospholipase C beta 1 | 19.494 | 1.239 | 0.0438 |
| Map9 | Microtubule associated protein 9 | 15.383 | 1.238 | 0.0815 |
| Jakmip2 | Janus kinase and microtubule interacting protein 2 | 11.357 | 1.236 | 0.0491 |
| Pura | Purine rich element binding protein A | 19.084 | 1.236 | 0.019 |
| Hsp90b1 | Heat shock protein 90 beta family member 1 | 65.468 | 1.235 | 0.027 |
| Ncl | Nucleolin | 18.087 | 1.235 | 0.0652 |
| Neto1 | Neuropilin and tolloid like 1 | 16.105 | 1.233 | 0.0711 |
| Gda | Guanine deaminase | 30.573 | 1.232 | 0.0364 |
| Cnr1 | Cannabinoid receptor 1 | 25.574 | 1.231 | 0.0575 |
| Bhlhb9 | Basic helix-loop-helix family member b9 | 16.07 | 1.229 | 0.0355 |
| Ythdc1 | YTH domain containing 1 | 13.542 | 1.228 | 0.0578 |
| Golga4 | Golgin A4 | 10.017 | 1.226 | 0.0576 |
| Cir1 | Corepressor interacting with RBPJ, 1 | 10.903 | 1.224 | 0.0657 |
| Mzt1 | Mitotic spindle organizing protein 1 | 27.367 | 1.224 | 0.0631 |
| Rnf6 | Ring finger protein 6 | 10.488 | 1.224 | 0.0599 |
| Gdap1 | Ganglioside induced differentiation associated protein 1 | 20.359 | 1.223 | 0.0596 |
| Lpgat1 | Lysophosphatidylglycerol acyltransferase 1 | 20.943 | 1.221 | 0.0473 |
| Pin4 | Peptidylprolyl cis/trans isomerase, NIMA-interacting 4 | 14.967 | 1.221 | 0.085 |
| Cpne7 | Copine 7 | 93.847 | 1.220 | 0.0478 |
| Ggnbp2 | Gametogenetin binding protein 2 | 18.355 | 1.216 | 0.0902 |
| Etv1 | ETS variant transcription factor 1 | 14.066 | 1.215 | 0.0518 |
| Arl5a | ADP ribosylation factor like GTPase 5A | 15.424 | 1.214 | 0.0924 |
| Pafah1b1 | Platelet activating factor acetylhydrolase 1b regulatory subunit 1 | 59.969 | 1.213 | 0.0964 |
| Tafa1 | TAFA chemokine like family member 1 | 11.298 | 1.213 | 0.0663 |
| Srsf3 | Serine and arginine rich splicing factor 3 | 27.672 | 1.212 | 0.044 |
| Tceal9 | Transcription elongation factor A like 9 | 29.46 | 1.212 | 0.0939 |
| Ccdc47 | Coiled-coil domain containing 47 | 14.385 | 1.211 | 0.0885 |
| Tim2 | Tripartite motif containing 2 | 46.277 | 1.211 | 0.072 |
| Aff4 | AF4/FMR2 family member 4 | 15.746 | 1.210 | 0.093 |
| C5orf24 | Chromosome 5 open reading frame 24 | 18.903 | 1.210 | 0.0917 |
| Msantd4 | Myb/SANT DNA binding domain containing 4 with coiled-coils | 14.084 | 1.208 | 0.0552 |
| Rab39b | RAB39B, member RAS oncogene family | 10.444 | 1.208 | 0.087 |
| Vxn | Vexin | 56.093 | 1.207 | 0.0472 |
| Tmem33 | Transmembrane protein 33 | 10.859 | 1.205 | 0.0876 |
| Slk | STE20 like kinase | 10.826 | 1.204 | 0.0747 |
| Hdgfl3 | HDGF like 3 | 11.325 | 1.202 | 0.0891 |
| Dynlt3 | Dynein light chain Tctex-type 3 | 39.421 | 1.201 | 0.0859 |
| Dyrk2 | Dual specificity tyrosine phosphorylation regulated kinase 2 | 10.698 | 1.200 | 0.0429 |