Table 4b.
Subset of significantly affected gene ontology categories involved in molecular functions. Green, negative fold changes indicate downregulation. Red, positive fold changes indicate upregulation.
| GO term | Description | Detected Genes | DE Genes | DE Genes (Names) | P-values |
|---|---|---|---|---|---|
| 0033592 | RNA strand annealing activity | 3 | 2 | Fmr1, Fxr1 | 2.18E-04 |
| 0097100 | Supercoiled DNA binding | 3 | 2 | Psip1, Top1 | 2.18E-04 |
| 0070840 | Dynein complex binding | 21 | 3 | Fmr1, Pafah1b1, Smc3 | 7.32E-04 |
| 0051082 | Unfolded protein binding | 61 | 4 | Dnajb4, Hsp90aa1, Hsp90b1, Hspa5 | 1.85E-03 |
| 0002151 | G-quadruplex RNA binding | 9 | 2 | Fmr1, Fxr1 | 2.52E-03 |
| 0062061 | TAP complex binding | 9 | 2 | H2-D1, H2-K1 | 2.52E-03 |
| 0031720 | Haptoglobin binding | 9 | 2 | Hba-a2, Hbb-bs | 2.52E-03 |
| 0019911 | Structural constituent of myelin sheath | 10 | 2 | Mbp, Pllp | 3.14E-03 |
| 0030881 | Beta-2-microglobulin binding | 11 | 2 | H2-D1, H2-K1 | 3.81E-03 |
| 0042610 | CD8 receptor binding | 11 | 2 | H2-D1, H2-K1 | 3.81E-03 |
| 0046977 | TAP binding | 11 | 2 | H2-D1, H2-K1 | 3.81E-03 |
| 0003743 | Translation initiation factor activity | 38 | 3 | Eif3a, Eif5, Eif5b | 4.18E-03 |
| 1990825 | Sequence-specific mRNA binding | 13 | 2 | Fmr1, Srsf3 | 5.35E-03 |
| 0022851 | GABA-gated chloride ion channel activity | 13 | 2 | Gabra2, Gabrb1 | 5.35E-03 |
| 0097001 | Ceramide binding | 14 | 2 | Mag, Pltp | 6.20E-03 |
| 0042608 | T cell receptor binding | 15 | 2 | H2-D1, H2-K1 | 7.12E-03 |
| 0004113 | 2’,3’-cyclic-nucleotide 3’-phosphodiesterase activity | 1 | 1 | Cnp | 8.57E-03 |
| 0004148 | Dihydrolipoyl dehydrogenase activity | 1 | 1 | Dld | 8.57E-03 |
| 0043544 | Lipoamide binding | 1 | 1 | Dld | 8.57E-03 |
| 0080132 | Fatty acid alpha-hydroxylase activity | 1 | 1 | Fa2h | 8.57E-03 |
| 0008892 | Guanine deaminase activity | 1 | 1 | Gda | 8.57E-03 |
| 0052858 | Peptidyl-lysine acetyltransferase activity | 1 | 1 | Naa50 | 8.57E-03 |
| 1990631 | ErbB-4 class receptor binding | 1 | 1 | Ncl | 8.57E-03 |
| 0047933 | Glucose-1,6-bisphosphate synthase activity | 1 | 1 | Pgm2l1 | 8.57E-03 |
| 0140339 | Phosphatidylglycerol transfer activity | 1 | 1 | Pltp | 8.57E-03 |
| 0140340 | Cerebroside transfer activity | 1 | 1 | Pltp | 8.57E-03 |
| 0140337 | Diacylglyceride transfer activity | 1 | 1 | Pltp | 8.57E-03 |
| 0140338 | Sphingomyelin transfer activity | 1 | 1 | Pltp | 8.57E-03 |
| 0051717 | Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity | 1 | 1 | Pten | 8.57E-03 |
| 0051800 | Phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity | 1 | 1 | Pten | 8.57E-03 |
| 0001761 | Beta-alanine transmembrane transporter activity | 1 | 1 | Slc6a6 | 8.57E-03 |
| 0005369 | Taurine:sodium symporter activity | 1 | 1 | Slc6a6 | 8.57E-03 |
| 0004890 | GABA-A receptor activity | 18 | 2 | Gabra2, Gabrb1 | 0.010198 |
| 0019825 | Oxygen binding | 18 | 2 | Hba-a2, Hbb-bs | 0.010198 |
| 0031489 | Myosin V binding | 20 | 2 | Rab39b, Rab3c | 0.012524 |
| 0043022 | Ribosome binding | 57 | 3 | Fmr1, Hspa5, Impact | 0.01287 |
| 0008139 | Nuclear localization sequence binding | 21 | 2 | Kpna3, Nfkbia | 0.013765 |
| 0005104 | Fibroblast growth factor receptor binding | 22 | 2 | Fgf12, Nrxn1 | 0.015057 |
| 0001671 | ATPase activator activity | 23 | 2 | Dnaja1, Dnajb4 | 0.0164 |
| 0004351 | Glutamate decarboxylase activity | 2 | 1 | Gad2 | 0.017065 |
| 0031722 | Hemoglobin beta binding | 2 | 1 | Hbb-bs | 0.017065 |
| 0002135 | CTP binding | 2 | 1 | Hsp90aa1 | 0.017065 |
| 0099609 | Microtubule lateral binding | 2 | 1 | Kif5b | 0.017065 |
| 0004823 | Leucine-tRNA ligase activity | 2 | 1 | Lars2 | 0.017065 |
| 0045547 | Dehydrodolichyl diphosphate synthase activity | 2 | 1 | Nus1 | 0.017065 |
| 0120019 | Phosphatidylcholine transfer activity | 2 | 1 | Pltp | 0.017065 |
| 0030977 | Taurine binding | 2 | 1 | Slc6a6 | 0.017065 |
| 0086038 | Calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential | 2 | 1 | Slc8a1 | 0.017065 |
| 0099580 | Ion antiporter activity involved in regulation of postsynaptic membrane potential | 2 | 1 | Slc8a1 | 0.017065 |
| 0032810 | Sterol response element binding | 2 | 1 | Srebf1 | 0.017065 |
| 0004775 | Succinate-CoA ligase (ADP-forming) activity | 2 | 1 | Sucla2 | 0.017065 |
| 0034986 | Iron chaperone activity | 2 | 1 | Trf | 0.017065 |
| 0019781 | NEDD8 activating enzyme activity | 2 | 1 | Uba3 | 0.017065 |
| 0048027 | mRNA 5’-UTR binding | 24 | 2 | Fmr1, Ncl | 0.017791 |
| 0044183 | Protein folding chaperone | 26 | 2 | Hsp90aa1, Hspa5 | 0.020718 |
| 0035064 | Methylated histone binding | 70 | 3 | Atrx, Fmr1, Mphosph8 | 0.022223 |
| 0048306 | Calcium-dependent protein binding | 70 | 3 | Nrxn1, S100a1, Wfs1 | 0.022223 |
| 0042605 | Peptide antigen binding | 27 | 2 | H2-D1, H2-K1 | 0.022251 |
| 0042165 | Neurotransmitter binding | 28 | 2 | Chrm3, Slc6a6 | 0.02383 |
| 0050750 | Low-density lipoprotein particle receptor binding | 28 | 2 | Dnaja1, Hsp90b1 | 0.02383 |
| 0008081 | Phosphoric diester hydrolase activity | 72 | 3 | Cnp, Pde1a, Plcb1 | 0.023917 |
| 0004949 | Cannabinoid receptor activity | 3 | 1 | Cnr1 | 0.025489 |
| 0044729 | Hemi-methylated DNA-binding | 3 | 1 | Egr1 | 0.025489 |
| 0051033 | RNA transmembrane transporter activity | 3 | 1 | Hnrnpa3 | 0.025489 |
| 0017098 | Sulfonylurea receptor binding | 3 | 1 | Hsp90aa1 | 0.025489 |
| 1905576 | Ganglioside GT1b binding | 3 | 1 | Mag | 0.025489 |
| 0042134 | rRNA primary transcript binding | 3 | 1 | Ncl | 0.025489 |
| 0004719 | Protein-L-isoaspartate (D-aspartate) O-methyltransferase activity | 3 | 1 | Pcmtd1 | 0.025489 |
| 0048101 | Calcium-and calmodulin-regulated 3’,5’-cyclic-GMP phosphodiesterase activity | 3 | 1 | Pde1a | 0.025489 |
| 0004117 | Calmodulin-dependent cyclic-nucleotide phosphodiesterase activity | 3 | 1 | Pde1a | 0.025489 |
| 0003681 | Bent DNA binding | 3 | 1 | Pin4 | 0.025489 |
| 0016314 | Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity | 3 | 1 | Pten | 0.025489 |
| 0070139 | SUMO-specific endopeptidase activity | 3 | 1 | Senp6 | 0.025489 |
| 1905060 | Calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration | 3 | 1 | Slc8a1 | 0.025489 |
| 0003917 | DNA topoisomerase type I activity | 3 | 1 | Top1 | 0.025489 |
| 0071074 | Eukaryotic initiation factor eIF2 binding | 4 | 1 | Eif5 | 0.033841 |
| 0031721 | Hemoglobin alpha binding | 4 | 1 | Hbb-bs | 0.033841 |
| 0032564 | dATP binding | 4 | 1 | Hsp90aa1 | 0.033841 |
| 0032551 | Pyrimidine ribonucleoside binding | 4 | 1 | Hsp90aa1 | 0.033841 |
| 0002134 | UTP binding | 4 | 1 | Hsp90aa1 | 0.033841 |
| 0044547 | DNA topoisomerase binding | 4 | 1 | Ncl | 0.033841 |
| 0097109 | Neuroligin family protein binding | 4 | 1 | Nrxn1 | 0.033841 |
| 0032422 | Purine-rich negative regulatory element binding | 4 | 1 | Pura | 0.033841 |
| 0015349 | Thyroid hormone transmembrane transporter activity | 4 | 1 | Slco1c1 | 0.033841 |
| 0042162 | Telomeric DNA binding | 34 | 2 | Ncl, Pura | 0.03421 |
| 0031369 | Translation initiation factor binding | 35 | 2 | Eif5, Fmr1 | 0.036084 |
| 0060590 | ATPase regulator activity | 37 | 2 | Dnaja1, Dnajb4 | 0.039946 |
| 0070087 | Chromo shadow domain binding | 5 | 1 | Atrx | 0.042122 |
| 0015616 | DNA translocase activity | 5 | 1 | Atrx | 0.042122 |
| 0055131 | C3HC4-type RING finger domain binding | 5 | 1 | Dnaja1 | 0.042122 |
| 0005131 | Growth hormone receptor binding | 5 | 1 | Gh | 0.042122 |
| 0051022 | Rho GDP-dissociation inhibitor binding | 5 | 1 | Hsp90aa1 | 0.042122 |
| 0005105 | Type 1 fibroblast growth factor receptor binding | 5 | 1 | Nrxn1 | 0.042122 |
| 0036033 | Mediator complex binding | 5 | 1 | Smc3 | 0.042122 |
| 0035255 | Ionotropic glutamate receptor binding | 39 | 2 | Neto1, Pten | 0.043957 |
| 0047676 | Arachidonate-CoA ligase activity | 6 | 1 | Acsl4 | 0.050333 |
| 0016907 | G-protein coupled acetylcholine receptor activity | 6 | 1 | Chrm3 | 0.050333 |
| 0034604 | Pyruvate dehydrogenase (NAD+) activity | 6 | 1 | Dld | 0.050333 |
| 0035368 | Selenocysteine insertion sequence binding | 6 | 1 | Ncl | 0.050333 |
| 0019992 | Diacylglycerol binding | 6 | 1 | Pltp | 0.050333 |
| 1990050 | Phosphatidic acid transporter activity | 6 | 1 | Pltp | 0.050333 |
| 1904121 | Phosphatidylethanolamine transporter activity | 6 | 1 | Pltp | 0.050333 |
| 0004791 | Thioredoxin-disulfide reductase activity | 6 | 1 | Selenot | 0.050333 |
| 0005332 | Gamma-aminobutyric acid:sodium symporter activity | 6 | 1 | Slc6a6 | 0.050333 |
| 0004601 | Peroxidase activity | 44 | 2 | Hba-a2, Hbb-bs | 0.054596 |
| 0099635 | Voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels | 7 | 1 | Cnr1 | 0.058473 |
| 0010385 | Double-stranded methylated DNA binding | 7 | 1 | Egr1 | 0.058473 |
| 0030911 | TPR domain binding | 7 | 1 | Hsp90aa1 | 0.058473 |
| 1905538 | Polysome binding | 7 | 1 | Impact | 0.058473 |
| 1904315 | Transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential | 47 | 2 | Gabra2, Gabrb1 | 0.061369 |
| 0061797 | pH-gated chloride channel activity | 48 | 2 | Gabra2, Gabrb1 | 0.063687 |
| 0030235 | Nitric-oxide synthase regulator activity | 8 | 1 | Hsp90aa1 | 0.066545 |
| 0031995 | Insulin-like growth factor II binding | 8 | 1 | Igfbp5 | 0.066545 |
| 0010997 | Anaphase-promoting complex binding | 8 | 1 | Pten | 0.066545 |
| 1990247 | N6-methyladenosine-containing RNA binding | 8 | 1 | Ythdc1 | 0.066545 |
| 0008028 | Monocarboxylic acid transmembrane transporter activity | 52 | 2 | Slc6a6, Slco1c1 | 0.073247 |
| 0031957 | Very long-chain fatty acid-CoA ligase activity | 9 | 1 | Acsl4 | 0.074547 |
| 0030957 | Tat protein binding | 9 | 1 | Dnaja1 | 0.074547 |
| 0034046 | Poly(G) binding | 9 | 1 | Fmr1 | 0.074547 |
| 0003691 | Double-stranded telomeric DNA binding | 9 | 1 | Pura | 0.074547 |
| 0005544 | Calcium-dependent phospholipid binding | 53 | 2 | Anxa5, Cpne7 | 0.075705 |
| 0035197 | siRNA binding | 10 | 1 | Fmr1 | 0.082482 |
| 0045159 | Myosin II binding | 10 | 1 | Gsn | 0.082482 |
| 0043208 | Glycosphingolipid binding | 10 | 1 | Mag | 0.082482 |
| 0008199 | Ferric iron binding | 10 | 1 | Trf | 0.082482 |
| 0005388 | Calcium-transporting ATPase activity | 11 | 1 | Anxa5 | 0.090349 |
| 0004143 | Diacylglycerol kinase activity | 11 | 1 | Dgkb | 0.090349 |
| 0016274 | Protein-arginine N-methyltransferase activity | 11 | 1 | Fbxo11 | 0.090349 |
| 0008503 | Benzodiazepine receptor activity | 11 | 1 | Gabra2 | 0.090349 |
| 0008429 | Phosphatidylethanolamine binding | 11 | 1 | Pltp | 0.090349 |
| 1901611 | Phosphatidylglycerol binding | 11 | 1 | Pltp | 0.090349 |
| 0005086 | ARF guanyl-nucleotide exchange factor activity | 11 | 1 | Psd3 | 0.090349 |
| 1990459 | Transferrin receptor binding | 11 | 1 | Trf | 0.090349 |
| 0019829 | Inorganic cation-transporting ATPase activity | 59 | 2 | Anxa5, mt-Atp6 | 0.09098 |
| 0042625 | ATPase coupled ion transmembrane transporter activity | 61 | 2 | Anxa5, mt-Atp6 | 0.096257 |
| 0000900 | Translation repressor activity, mRNA regulatory element binding | 12 | 1 | Pura | 0.098149 |
| 0044548 | S100 protein binding | 12 | 1 | S100a1 | 0.098149 |
| 0042910 | Xenobiotic transporter activity | 12 | 1 | Slc6a6 | 0.098149 |