Table 4c.
Subset of significantly affected gene ontology categories forming cellular components. Green, negative fold changes indicate downregulation. Red, positive fold changes indicate upregulation.
| GO term | Description | Total Genes | DE Genes | DE Genes (Names) | P-values |
|---|---|---|---|---|---|
| 0043218 | Compact myelin | 5 | 4 | Mag, Mbp, Pllp, Pmp22 | 2.639E-07 |
| 0043209 | Myelin sheath | 182 | 12 | Cldn11, Cnp, Dld, Gjc2, Gsn, Hsp90aa1, Hspa5, Mag, Mbp, Mog, Plcb1, Sucla2 | 2.427E-05 |
| 0035749 | Myelin sheath adaxonal region | 6 | 3 | Cnp, Mag, Pten | 6.830E-05 |
| 0000235 | Astral microtubule | 8 | 3 | Dynlt3, Map9, Pafah1b1 | 1.869E-04 |
| 0098982 | GABA-ergic synapse | 104 | 8 | Camk4, Cnr1, Gabra2, Gabrb1, Gabrd, Nrxn1, Plcb1, Slc6a6 | 1.951E-04 |
| 1990015 | Ensheathing process | 2 | 2 | Mag, Myoc | 2.329E-04 |
| 0097453 | Mesaxon | 2 | 2 | Mag, Myoc | 2.329E-04 |
| 0043197 | Dendritic spine | 181 | 10 | Akap5, Arc, Fmr1, Fxr1, Homer1, Lpar1, Mob4, Pten, Slc8a1, Syndig1 | 4.823E-04 |
| 0043198 | Dendritic shaft | 69 | 6 | Akap5, Hcn1, Homer1, Lpar1, Slc8a1, Syndig1 | 6.462E-04 |
| 0034663 | Endoplasmic reticulum chaperone complex | 12 | 3 | Hsp90b1, Hspa5, Sdf2l1 | 7.018E-04 |
| 0042824 | MHC class I peptide loading complex | 14 | 3 | B2m, H2-D1, H2-K1 | 1.135E-03 |
| 0005790 | Smooth endoplasmic reticulum | 31 | 4 | Dnajc3, Fmr1, Hsp90b1, Hspa5 | 1.214E-03 |
| 0043220 | Schmidt-Lanterman incisure | 15 | 3 | Mag, Myoc, Pten | 1.403E-03 |
| 1902737 | Dendritic filopodium | 5 | 2 | Fmr1, Fxr1 | 2.259E-03 |
| 0030139 | Endocytic vesicle | 154 | 8 | Gsn, Kif5b, Lpar1, Nrxn1, Rab8b, Rab9b, Rabep1, Trf | 2.573E-03 |
| 1990712 | HFE-transferrin receptor complex | 6 | 2 | B2m, Trf | 3.354E-03 |
| 0031415 | NatA complex | 6 | 2 | Naa15, Naa50 | 3.354E-03 |
| 0001651 | Dense fibrillar component | 6 | 2 | Ncl, Top1 | 3.354E-03 |
| 0042579 | Microbody | 127 | 7 | Acbd5, Acsl4, Crot, Idi1, Pex13, Pnpla8, Rab8b | 3.400E-03 |
| 0030670 | Phagocytic vesicle membrane | 21 | 3 | B2m, H2-D1, H2-K1 | 3.832E-03 |
| 0005797 | Golgi medial cisterna | 23 | 3 | H2-D1, H2-K1, Yipf6 | 4.990E-03 |
| 0060076 | Excitatory synapse | 46 | 4 | Akap5, Homer1, Neto1, Syndig1 | 5.266E-03 |
| 0060077 | Inhibitory synapse | 24 | 3 | Gabra2, Gad2, Nrxn1 | 5.639E-03 |
| 0005844 | Polysome | 47 | 4 | Fmr1, Fxr1, Impact, Upf2 | 5.688E-03 |
| 0030666 | Endocytic vesicle membrane | 26 | 3 | B2m, H2-D1, H2-K1 | 7.083E-03 |
| 0099524 | Postsynaptic cytosol | 26 | 3 | Fmr1, Homer1, Pten | 7.083E-03 |
| 0005876 | Spindle microtubule | 51 | 4 | Bod1l, Dynlt3, Map9, Pafah1b1 | 7.600E-03 |
| 0035748 | Myelin sheath abaxonal region | 9 | 2 | Cnp, Myoc | 7.809E-03 |
| 0044326 | Dendritic spine neck | 9 | 2 | Fmr1, Fxr1 | 7.809E-03 |
| 0005833 | Hemoglobin complex | 9 | 2 | Hba-a2, Hbb-bs | 7.809E-03 |
| 0051286 | Cell tip | 10 | 2 | Rab8b, Trf | 9.663E-03 |
| 0005777 | Peroxisome | 119 | 6 | Acbd5, Acsl4, Crot, Idi1, Pex13, Pnpla8 | 9.958E-03 |
| 0098845 | Postsynaptic endosome | 12 | 2 | Akap5, Arc | 0.0139 |
| 0009898 | Cytoplasmic side of plasma membrane | 61 | 4 | Akap5, G6pdx, Litaf, Pten | 0.0141 |
| 1990707 | Nuclear subtelomeric heterochromatin | 1 | 1 | Atrx | 0.0153 |
| 0030990 | Intraciliary transport particle | 1 | 1 | Dync2li1 | 0.0153 |
| 0005969 | Serine-pyruvate aminotransferase complex | 1 | 1 | Eea1 | 0.0153 |
| 0071540 | Eukaryotic translation initiation factor 3 complex, eIF3e | 1 | 1 | Eif3a | 0.0153 |
| 0016028 | Rhabdomere | 1 | 1 | Mertk | 0.0153 |
| 0034678 | Integrin alpha8-beta1 complex | 1 | 1 | Npnt | 0.0153 |
| 0005943 | Phosphatidylinositol 3-kinase complex, class IA | 1 | 1 | Pik3ca | 0.0153 |
| 0045239 | Tricarboxylic acid cycle enzyme complex | 13 | 2 | Dld, Sucla2 | 0.0163 |
| 1902711 | GABA-A receptor complex | 13 | 2 | Gabra2, Gabrb1 | 0.0163 |
| 0071556 | Integral component of lumenal side of endoplasmic reticulum membrane | 13 | 2 | H2-D1, H2-K1 | 0.0163 |
| 1990124 | Messenger ribonucleoprotein complex | 14 | 2 | Fmr1, Hnrnpa3 | 0.0188 |
| 0005778 | Peroxisomal membrane | 38 | 3 | Pex13, Pnpla8, Rab8b | 0.0201 |
| 0032590 | Dendrite membrane | 39 | 3 | Akap5, Gabra2, Hcn1 | 0.0215 |
| 0098839 | Postsynaptic density membrane | 39 | 3 | Arc, Neto1, Syndig1 | 0.0215 |
| 0099522 | Region of cytosol | 40 | 3 | Fmr1, Homer1, Pten | 0.0230 |
| 0005753 | Mitochondrial proton-transporting ATP synthase complex | 16 | 2 | mt-Atp6, mt-Atp8 | 0.0243 |
| 0099634 | Postsynaptic specialization membrane | 41 | 3 | Arc, Neto1, Syndig1 | 0.0246 |
| 0045178 | Basal part of cell | 17 | 2 | Cldn11, Trf | 0.0272 |
| 0033270 | Paranode region of axon | 17 | 2 | Gjc2, Mag | 0.0272 |
| 0055037 | Recycling endosome | 113 | 5 | Akap5, Avl9, Eea1, Mctp1, Trf | 0.0298 |
| 0032433 | Filopodium tip | 18 | 2 | Fmr1, Fzd3 | 0.0303 |
| 0030140 | Trans-Golgi network transport vesicle | 18 | 2 | Gopc, Rab8b | 0.0303 |
| 0072563 | Endothelial microparticle | 2 | 1 | Anxa5 | 0.0303 |
| 0043614 | Multi-eIF complex | 2 | 1 | Eif3a | 0.0303 |
| 0032998 | Fc-epsilon receptor I complex | 2 | 1 | Fcer1g | 0.0303 |
| 0061202 | Clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane | 2 | 1 | Gad2 | 0.0303 |
| 0097226 | Sperm mitochondrial sheath | 2 | 1 | Hsp90aa1 | 0.0303 |
| 0098560 | Cytoplasmic side of late endosome membrane | 2 | 1 | Litaf | 0.0303 |
| 0005818 | Aster | 2 | 1 | Map9 | 0.0303 |
| 1904423 | Dehydrodolichyl diphosphate synthase complex | 2 | 1 | Nus1 | 0.0303 |
| 0030426 | Growth cone | 197 | 7 | Cnr1, Fmr1, Fxr1, Hsp90aa1, Kif5b, Nrxn1, Pafah1b1 | 0.0321 |
| 0044449 | Contractile fiber part | 198 | 7 | Anxa5, Fxr1, Homer1, Jph1, Npnt, S100a1, Slc8a1 | 0.0328 |
| 0044295 | Axonal growth cone | 46 | 3 | Hsp90aa1, Kif5b, Nrxn1 | 0.0331 |
| 0090723 | Growth cone part | 19 | 2 | Fmr1, Pafah1b1 | 0.0336 |
| 0043034 | Costamere | 19 | 2 | Fxr1, Homer1 | 0.0336 |
| 0005922 | Connexin complex | 19 | 2 | Gjb1, Gjc2 | 0.0336 |
| 0043679 | Axon terminus | 121 | 5 | Anxa5, Chrm3, Fmr1, Hcn1, Slc8a1 | 0.0383 |
| 0045335 | Phagocytic vesicle | 83 | 4 | Gsn, Kif5b, Rab8b, Rab9b | 0.0384 |
| 0030018 | Z disc | 124 | 5 | Anxa5, Homer1, Jph1, S100a1, Slc8a1 | 0.0418 |
| 0099055 | Integral component of postsynaptic membrane | 167 | 6 | Chrm3, Gabra2, Gabrd, Neto1, Slc6a6, Slc8a1 | 0.0435 |
| 0005921 | Gap junction | 22 | 2 | Gjb1, Gjc2 | 0.0440 |
| 0098855 | HCN channel complex | 3 | 1 | Hcn1 | 0.0452 |
| 0097524 | Sperm plasma membrane | 3 | 1 | Hsp90aa1 | 0.0452 |
| 0014701 | Junctional sarcoplasmic reticulum membrane | 3 | 1 | Jph1 | 0.0452 |
| 0098559 | Cytoplasmic side of early endosome membrane | 3 | 1 | Litaf | 0.0452 |
| 0034457 | Mpp10 complex | 3 | 1 | Mphosph10 | 0.0452 |
| 1990415 | Pex17p-Pex14p docking complex | 3 | 1 | Pex13 | 0.0452 |
| 0042709 | Succinate-CoA ligase complex | 3 | 1 | Sucla2 | 0.0452 |
| 0035327 | Transcriptionally active chromatin | 23 | 2 | Aff4, Psip1 | 0.0477 |
| 0031307 | Integral component of mitochondrial outer membrane | 24 | 2 | Armcx3, Gdap1 | 0.0515 |
| 0032279 | Asymmetric synapse | 25 | 2 | Akap5, Chrm3 | 0.0555 |
| 0005868 | Cytoplasmic dynein complex | 25 | 2 | Dync2li1, Dynlt3 | 0.0555 |
| 0032783 | ELL-EAF complex | 4 | 1 | Aff4 | 0.0598 |
| 0043159 | Acrosomal matrix | 4 | 1 | Dld | 0.0598 |
| 0044308 | Axonal spine | 4 | 1 | Eea1 | 0.0598 |
| 1990812 | Growth cone filopodium | 4 | 1 | Fmr1 | 0.0598 |
| 0097444 | Spine apparatus | 4 | 1 | Fmr1 | 0.0598 |
| 0019034 | Viral replication complex | 4 | 1 | Fmr1 | 0.0598 |
| 0030478 | Actin cap | 4 | 1 | Gsn | 0.0598 |
| 0042567 | Insulin-like growth factor ternary complex | 4 | 1 | Igfbp5 | 0.0598 |
| 0035976 | Transcription factor AP-1 complex | 4 | 1 | Junb | 0.0598 |
| 0098574 | Cytoplasmic side of lysosomal membrane | 4 | 1 | Litaf | 0.0598 |
| 0033269 | Internode region of axon | 4 | 1 | Mbp | 0.0598 |
| 0031021 | Interphase microtubule organizing center | 4 | 1 | Mzt1 | 0.0598 |
| 0030289 | Protein phosphatase 4 complex | 4 | 1 | Ppp4r2 | 0.0598 |
| 0008305 | Integrin complex | 28 | 2 | Npnt, Pmp22 | 0.0679 |
| 0098563 | Intrinsic component of synaptic vesicle membrane | 63 | 3 | Gabra2, Rab3c, Wfs1 | 0.0719 |
| 0070971 | Endoplasmic reticulum exit site | 29 | 2 | H2-D1, H2-K1 | 0.0722 |
| 0031256 | Leading edge membrane | 146 | 5 | Akap5, Gabra2, Hcn1, Hsp90aa1, Psd3 | 0.0737 |
| 0061673 | Mitotic spindle astral microtubule | 5 | 1 | Dynlt3 | 0.0741 |
| 0044094 | Host cell nuclear part | 5 | 1 | Fmr1 | 0.0741 |
| 1990769 | Proximal neuron projection | 5 | 1 | Gjc2 | 0.0741 |
| 0030485 | Smooth muscle contractile fiber | 5 | 1 | Npnt | 0.0741 |
| 0016586 | RSC complex | 5 | 1 | Pbrm1 | 0.0741 |
| 0034991 | Nuclear meiotic cohesin complex | 5 | 1 | Smc3 | 0.0741 |
| 0097433 | Dense body | 5 | 1 | Trf | 0.0741 |
| 0098984 | Neuron to neuron synapse | 30 | 2 | Akap5, Chrm3 | 0.0766 |
| 0030672 | Synaptic vesicle membrane | 66 | 3 | Gad2, Mctp1, Syndig1 | 0.0802 |
| 0005791 | Rough endoplasmic reticulum | 67 | 3 | Ccdc47, Clock, Fmr1 | 0.0830 |
| 0005726 | Perichromatin fibrils | 6 | 1 | Clock | 0.0883 |
| 0031466 | Cul5-RING ubiquitin ligase complex | 6 | 1 | Cul5 | 0.0883 |
| 0071598 | Neuronal ribonucleoprotein granule | 6 | 1 | Fmr1 | 0.0883 |
| 0008274 | Gamma-tubulin ring complex | 6 | 1 | Mzt1 | 0.0883 |
| 0090724 | Central region of growth cone | 6 | 1 | Pafah1b1 | 0.0883 |
| 0000932 | Cytoplasmic mRNA processing body | 72 | 3 | Dcp2, Pnrc2, Top1 | 0.0979 |
| 0032040 | Small-subunit processome | 35 | 2 | Krr1, Mphosph10 | 0.0997 |