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. 2022 Apr 5;15:985–1001. doi: 10.2147/JPR.S358942

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© 2022 Xu et al.

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Establishment of SMIR-induced chronic postoperative pain model and nocifensive behavioral evaluation. (A) Photo showing the surgery site and manipulations of the SMIR model (Left). Photos showing the recovery of the surgery site on days 7 and 14 (right). (B) Protocol for model establishment, behavioral assay and tissue collection. (C) 50% paw withdraw threshold (PWT) of ipsilateral hind paw of SMIR model rats vs sham group of rats. (D) Summary of normalized area under the curve (AUC) of time courses shown in panel (C). *p < 0.05 and **p<0.01 vs sham group. n = 6–7 rats/group.