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. Author manuscript; available in PMC: 2022 Apr 9.
Published in final edited form as: Trends Genet. 2020 Oct 19;37(1):12–20. doi: 10.1016/j.tig.2020.09.016

Figure 3. Epigenetic Evolution of Cryptocccus neoformans.

Figure 3.

Loss of a gene encoding a de novo DNA cytosine methyltransferase (DNMT) resulting in a long-lived lineage harboring only a maintenance-type DNA cytosine methyltransferase. This lineage gave rise of the human pathogenic yeast, Cryptococcus neoformans. Cytosine methylation patterns have been undergoing Darwinian evolution that is mediated by rare random loss events, rarer random gain events and the action of natural selection on the silencing of transposable elements.