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. 2022 Apr 9;46:101383. doi: 10.1016/j.eclinm.2022.101383

Figure 3.

Figure 3

Quantitative variables of immunogenicity in the three study groups by schedule and days.

Panels A and C shown anti-RBD IgG antibody titers for short and long schedules, respectively. Panels B and E shown inhibition of RBD-ACE-2 binding, for short and long schedules, respectively. Panels C and F shown Nab titers, for short and long schedules, respectively. Study groups are represented by colors, red for RBD 25 µg, blue for RBD 50 µg and gray for placebo. The boxes and horizontal bars indicate interquartile range (IQR) and median, respectively. The whisker's end points are the maximum and minimum values below or above the median ± 1•5 times the IQR. Points represent possible outliers. The braces contain the results of the Mann Whitney U multiple comparison tests with Bonferroni correction in cases where more than two groups appear (graphs A,B,D,E), and the Mann Whitney U tests in cases where only two groups appear (panels C and F). Only p values for significant differences are shown. Schedules: 0-14-28 days (short) and 0-28-56 days (long). RBD: receptor binding domain. ACE-2: angiotensin-converting enzyme. AU/mL: arbitrary units per mL. Nab: Neutralizing antibody titers.