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Phenothiazine C. neoformans SAR
| Compound | R | C. neoformans MIC (μg/mL) | pKa | ClogP | CNS MPO Score |
|---|---|---|---|---|---|
| 17a |
|
8 | 9.48 | 7.11 | 1.71 |
| 17b |
|
8 | 9.38 | 6.80 | 1.78 |
| 17c |
|
> 64 | 7.02 | 6.18 | 2.31 |
| 17d |
|
8 | 8.45 | 6.24 | 2.21 |
| 17e |
|
4 | 8.23 | 5.55 | 2.33 |
| 17f |
|
16 | 9.08 | 7.74 | 1.75 |
