Table 5.
Antifungal activity of 17d/e against fluconazole resistant-C. albicans
Entry | Strain | FLUa MIC (μg/mL) | MORb | 17d MIC (μg/mL) | 17e MIC (μg/mL) |
---|---|---|---|---|---|
1 | SC5314 | 0.25 | 1 | 8 | 8 |
2 | TWO7229 | 0.25 | 1 | 8 | 8 |
3 | TWO7230 | 2 | 2 | 8 | 8 |
4 | TWO7241 | 16 | 2, 3 | 8 | 8 |
5 | TWO7243 | 128 | 2, 3 | 8 | 8 |
Fluconazole (FLU); data are from reference 24.
MOR: Mechanism of resistance; 1) None; 2) Elevated efflux pump expression; 3) Elevated ERG11 expression;