FIG. 3.

Antileishmanial activity of a single dose of SA-PC liposomes in established experimental visceral leishmaniasis. BALB/c mice infected for 8 weeks were treated i.v. with 55 mg of SA-PC liposomes or with 50 mg of PC liposomes. Control infected animals were injected with PBS. Mice were sacrificed 1, 15, and 30 days after completion of treatment. The liver and spleen parasite burdens, expressed as Leishman-Donovan units (A), and weights of the liver and the spleen (B) were measured. Data shown are the mean ± standard error from one experiment representative of two performed.