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. 2022 Mar 15;9(4):582–596. doi: 10.1002/acn3.51539

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© 2022 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Schematic showing the locus coeruleus and its projections throughout the brain. Details of autonomic functions of the noradrenergic system are also shown. Actions of the noradrenergic system on cognition, as well as the nature of pathology seen in AD, and potential tools to modulate this system when dysfunctional are also shown. TH, thalamus; HYP, hypothalamus; SN, substantia nigra; VTA, ventral tegmental area; AMY, amygdala; HIP, hippocampus; LC, locus coeruleus; NTS, nucleus tractus solitarius.