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. 2022 Mar 4;9(4):564–569. doi: 10.1002/acn3.51522

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© 2022 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Differential age‐effects and determinants of plasma NfL levels and GCL volume. Advancing age was associated with an exponential increase in plasma NfL levels (A), and an exponential decrease in GCL volume (B). Standardized estimates derived from a multivariable regression model, assessing the independent effect of each specified determinant, showed both similarities and differences between determinants of plasma NfL levels and GCL (C). Abbreviations: GFR, glomerular filtration rate; SBP, systolic blood pressure; BMI, body‐mass index; GCL, ganglion cell layer volume; NfL, neurofilament light chain. * q < 0.05, ** q < 0.001, *** q < 0.0001. [Colour figure can be viewed at wileyonlinelibrary.com]