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. 2022 Mar 4;9(4):564–569. doi: 10.1002/acn3.51522

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© 2022 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Modifiers of the relation between retinal measures and plasma NfL levels. The unadjusted association between GCL and plasma NfL largely depended on age (A). After accounting for all potential confounders, the relation between GCL volume and NfL levels was strongly dependent on the presence of (risk factors for) neurodegeneration, including smoking (B) and a history of neurological disorders (C). Abbreviations: SBP, systolic blood pressure; GCL, ganglion cell layer volume; NfL, neurofilament light chain. [Colour figure can be viewed at wileyonlinelibrary.com]