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. 2022 Mar 15:eabn9243. doi: 10.1126/scitranslmed.abn9243

Fig. 4. Spike protein-specific, but not RBD-specific, Fc-mediated effector activity is preserved in samples from vaccinated individuals.

Fig. 4.

Antibody-dependent NK cell activation (ADNKA) was assessed by CD107a expression, a marker of NK cell degranulation, on CD3-CD56+ NK cells. Samples were incubated with D614G (blue) or Omicron (red) Spike (S) protein (circle) or RBD (square) and samples from recipients of 1 of 3 vaccine platforms: BNT162b2 (n=11), mRNA-1273 (n=13), and CoronaVac (n=13). The assay was performed with three different NK cell donors and the average value of all donors is shown. A two-sided Kruskal-Wallis test with a Benjamini-Hochberg post-test correcting for multiple comparisons was used to test for statistical differences between D614G and omicron. Significance was defined as p≤0.05 and only p-values for significantly different comparisons are shown.